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To study the effect of relocation from 3200m (Aksay) to 760m (Bishkek) in highlanders with High Altitude Pulmonary Hypertension (HAPH) who permanently live >2500m on 6-minute walk distance (6MWD)
This research in highlanders with HAPH diagnosed by echocardiography and defined by a RV/RA >30 mmHg who permanently live at HA >2500 m will perform a 6-minute walk distance test near their living altitude in Aksay at 3200 m and on day 2 and 7 at 760 m after relocation
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Assessments at 3200 m and 760 m, respectively | Experimental | Participants will have a 6-minute walk distance (6MWD) assessment near their resident altitude at 3200 m and after relocation to 760 m after 1 and 7 days. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 6-minute walk test (6MWT) | Other | 6-minute walk test (6MWT) will be performed according to clinical standards |
|
| Measure | Description | Time Frame |
|---|---|---|
| 6-minute walk distance (6MWD) on day 2 of relocation to 760 m | Change in 6MWD in meter between LA (760 m) vs HA (3200 m) | day 2 at 760 m compared to 3200 m |
| Measure | Description | Time Frame |
|---|---|---|
| 6-minute walk distance (6MWD) on day 7 of relocation to 760 m | 6-minute walk distance (6MWD) in meter between LA (760 m) and HA (3200 m) | day 7 at 760 m compared to 3200 m |
| Arterial oxygen saturation by pulseoximetry (SpO2) at rest and at peak 6MWD on day 2 of relocation to 760 m |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Talant M Sooronbaev, Prof. Dr. | National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov | Principal Investigator |
| Silvia Ulrich, Prof. Dr. | University Hospital Zurich, Department of Pulmonology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aksay Medical Center | Aksay Plateau, Naryn, Kyrgyzstan | Kyrgyzstan |
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Each highlander with HAPH will perform a 6 MWT at 3200 m and at 760 m according to a prospective study design
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Change in SpO2 in % between LA (760 m) vs HA (3200 m) |
| day 2 at 760 m compared to 3200 m |
| Arterial oxygen saturation by pulseoximetry (SpO2) at rest and at peak 6MWD on day 7 of relocation to 760 m | Change in SpO2 in % between LA (760 m) vs HA (3200 m) | day 7 at 760 m compared to 3200 m |
| Heart rate at rest and at peak 6MWD on day 2 of relocation to 760 m | Change in hear rate in bpm between LA (760 m) vs HA (3200 m) | after the first night at LA (760 m) |
| Heart rate at rest and at peak 6MWD on day 7 of relocation to 760 m | Change in hear rate in bpm between LA (760 m) vs HA (3200 m) | day 7 at 760 m compared to 3200 m |
| Blood pressure at rest and at 6MWD on day 2 of relocation to 760 m | Change in blood pressure in mmHg between LA (760 m) vs HA (3200 m) | day 2 at 760 m compared to 3200 m |
| Blood pressure at rest and at 6MWD on day 7 of relocation to 760 m | Change in blood pressure in mmHg between LA (760 m) vs HA (3200 m) | day 7 at 760 m compared to 3200 m |
| Borg Dyspnea scale at end 6MWT on day 2 of relocation to 760 m | Change of the Borg CR10 dyspnea scale at end of the 6MWT after the first night at LA (760 m) vs HA (3200 m) | day 2 at 760 m compared to 3200 m |
| Borg Dyspnea scale at end 6MWT on day 7 of relocation to 760 m | Change of the Borg CR10 dyspnea scale at end of the 6MWT after seven nights at LA (760 m) vs HA (3200 m) | day 7 at 760 m compared to 3200 m |
| Borg leg fatigue scale at end 6MWT on day 2 of relocation to 760 m | Change of the Borg CR10 leg fatigue scale at end of the 6MWT after the first night at LA (760 m) vs HA (3200 m) | day 2 at 760 m compared to 3200 m |
| Borg leg fatigue scale at end 6MWT on day 7 of relocation to 760 m | Change of the Borg CR10 leg fatigue scale at end of the 6MWT after seven nights at LA (760 m) vs HA (3200 m) | day 7 at 760 m compared to 3200 m |
| ID | Term |
|---|---|
| C535833 | Pulmonary edema of mountaineers |
| D006976 | Hypertension, Pulmonary |
| D000860 | Hypoxia |
| D000532 | Altitude Sickness |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012120 | Respiration Disorders |
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