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To study the effect of relocation from 3200 m (Aksay) to 760 m (Bishkek) in patients with high altitude pulmonary hypertension (HAPH) who permanently live >2500 m on pulmonary artery pressure (PAP)
This research in highlanders with HAPH diagnosed by echocardiography and defined by a RV/RA >30 mmHg who permanently live at HA >2500 m will have pulmonary arterial pressure (PAP) assessed by echocardiography near their living altitude in Aksay at 3200 m and at 760 m in Bishkek the day after the first and the seventh night after relocation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Assessments at 3200 m and 760 m, respectively | Experimental | Participants will have a echocardiography near their resident altitude at 3200 m and after relocation to 760 m after 1 and 7 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Echocardiography | Other | Echocardiography will be performed according to clinical standards |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Pulmonary artery Pressure (PAP) after the first night at 760 m (LA) vs at 3200 m (HA) | Change in RV/RA in mmHg assessed by echocardiography between LA (760 m) vs High altitude (3200 m) | day 2 at 760 m vs. 3200 m |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Pulmonary artery Pressure (PAP) after seven nights at 760 m (LA) vs at 3200 m (HA) | Change in RV/RA in mmHg assessed by echocardiography between LA (760 m) vs High altitude (3200 m) | day 7 at 760 m vs. 3200 m |
| Cardiac output at 760 m (LA) vs at 3200 m (HA) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Talant M Sooronbaev, Prof. Dr. | National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov | Principal Investigator |
| Silvia Ulrich, Prof. Dr. | University Hospital Zurich, Department of Pulmonology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aksay Medical Center | Aksay Plateau, Naryn, Kyrgyzstan, Kyrgyzstan | Kyrgyzstan |
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Each highlander with HAPH will perform a echocardiography at high altitude (HA, 3200 m) and day 2 and day 7 at low altitude (LA, 760 m) according to a prospective study design
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Change in cardiac output in l/min assessed by echocardiography between LA (760 m) vs HA (3200 m) |
| day 2 and 7 at 760 m vs. 3200 m |
| Tricuspid pressure gradient by echocardiography at 760 m (LA) vs at 3200 m (HA) | Tricuspid pressure gradient assessed by echocardiography between LA (760 m) vs HA (3200 m) | day 2 and 7 at 760 m vs. 3200 m |
| Tricupsid annular plane systolic excursion by echocardiography at 760 m (LA) vs at 3200 m (HA) | Tricupsid annular plane systolic excursion assessed by echocardiography between LA (760 m) vs HA (3200 m) | day 2 and 7 at 760 m vs. 3200 m |
| pH by arterial blood gases at 760 m (LA) vs at 3200 m (HA) | Change in pH by arterial blood gases assessed between LA (760 m) vs HA (3200 m) | day 2 and 7 at 760 m vs. 3200 m |
| partial pressure of oxygen (PaO2) by arterial blood gases at 760 m (LA) vs at 3200 m (HA) | Change in partial pressure of oxygen (PaO2) assessed by arterial blood gases between LA (760 m) vs HA (3200 m) | day 2 and 7 at 760 m vs. 3200 m |
| partial pressure of carbon dioxide (PaCO2) by arterial blood gases at 760 m (LA) vs at 3200 m (HA) | Change in partial pressure of carbon dioxide (PaCO2) assessed by arterial blood gases partial pressure of carbon dioxide (PaCO2) between LA (760 m) vs HA (3200 m) | after the first and seventh night at LA |
| Change in right to left heart diameter ratio at 760 m (LA) vs at 3200 m (HA) | Change in right to left heart diameter ratio assessed by echocardiography between LA (760 m) vs HA (3200 m) | day 2 and 7 at 760 m vs. 3200 m |
| Change in right atrial area at 760 m (LA) vs at 3200 m (HA) | Change in right atrial area by echocardiography between LA (760 m) vs HA (3200 m) | day 2 and 7 at 760 m vs. 3200 m |
| Change in right heart strain at 760 m (LA) vs at 3200 m (HA) | Change in right heart strain by echocardiography between LA (760 m) vs HA (3200 m) | day 2 and 7 at 760 m vs. 3200 m |
| Change in ECG morphology at 760 m (LA) vs at 3200 m (HA) | Change in ECG morphology and QT-interval by 12-lead ECG between LA (760 m) vs HA (3200 m) | day 2 and 7 at 760 m vs. 3200 m |
| ID | Term |
|---|---|
| C535833 | Pulmonary edema of mountaineers |
| D006976 | Hypertension, Pulmonary |
| D000860 | Hypoxia |
| D000532 | Altitude Sickness |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012120 | Respiration Disorders |
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