Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Little is known about affection of small airways in patients with pulmonary hypertension as well as the ideal diagnostic approach. The investigators therefore aimed to evaluate novel or not widely used lung function tests for the evaluation of airway function in patients with PH.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PH patients | Patients with known or first diagnosis of PH |
| |
| healthy controls | Healthy controls had normal lung function testing including whole-body plethysmography and transfer factor, no previously diagnosed pulmonary disease as well as no respiratory symptoms. |
| |
| non-healthy controls | Non-healthy controls were allowed to have stable pulmonary comorbidities including chronic obstructive pulmonary disease (COPD), sarcoidosis, asthma, or fibrosis as well as non-pulmonary comorbidities. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| body plethysmography | Diagnostic Test | measurement of conventional lung function parameters |
|
| Measure | Description | Time Frame |
|---|---|---|
| LCI | between-group difference in lung clearance index (LCI) | 30 minutes |
| D5-20 | between-group difference in frequency dependence of resistance (D5-20) | 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Discrimination small airway resistance | Evaluation of discriminative capability of impulse oscillometry | 30 minutes |
| Discrimination ventilation heterogeneity | Evaluation of discriminative capability of multiple breath washout |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
PH group: known or first diagnosis of PH
Healthy controls: normal lung function testing including whole-body plethysmography and transfer factor, no previously diagnosed pulmonary disease as well as no respiratory symptoms.
Non-healthy controls: stable pulmonary comorbidities including COPD, sarcoidosis, asthma, or fibrosis as well as non-pulmonary comorbidities.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Frederik Trinkmann, MD | Universitätsmedizin Mannheim | Principal Investigator |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D006976 | Hypertension, Pulmonary |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D010993 | Plethysmography, Whole Body |
| ID | Term |
|---|---|
| D010991 | Plethysmography |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
Not provided
Not provided
Not provided
Not provided
Not provided
| impulse oscillometry | Diagnostic Test | measurement of central and peripheral airway resistance |
|
| multiple breath washout | Diagnostic Test | measurement of ventilation heterogeneity |
|
| 30 minutes |
| D002318 |
| Cardiovascular Diseases |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |