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slow recruitment
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| Name | Class |
|---|---|
| Ludwig Boltzmann Institute for Lung Vascular Research | OTHER |
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The aim of the study is to determine relevant morphologic parameters of the lung vasculature for the differentiation between different groups of patients with pulmonary hypertension (PH) by thoracic computer tomography (CT). In this pilot study patients undergoing right heart catheterization will be investigated by thoracic CT and special software to determine morphologic readouts.
The investigators expect that using this non-invasive method, parameters relevant for the differentiation of the patients with PH can be determined.
Pulmonary hypertension (PH) is defined as an elevated mean pressure in the pulmonary artery above 20mmHg determined at right-heart catheterization. Depending on the presentation and pathogenesis, patients are classified according to five main groups. A correct classification is crucial, since it is essential for the available therapy options.
A promising non-invasive method to provide important hemodynamic and clinical Information is the fully-automatic analysis of thoracic computed tomography images. This method can yield a number of quantitative morphologic readouts of the lung vasculature and the parenchyma.
This study aims to identify quantitative markers from the fully-automatic image analysis, which allow a discrimination between the various PH patient groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pulmonary arterial hypertension (PAH) | The patients with PAH received an invasive right-heart catheterization and a thoracic CT scan as part of their routine work up. |
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| PH due to left-heart disease (PH-LHD) | The patients with PH-LHD received an invasive right-heart catheterization and a thoracic CT scan as part of their routine work up. |
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| Chronic thromboembolic pulmonary hypertension (CTEPH) | The patients with CTEPH received an invasive right-heart catheterization and a thoracic CT scan as part of their routine work up. |
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| PH due to emphysema (PH-LD-Emphys) | The patients with PH-LD-Emphys received an invasive right-heart catheterization and a thoracic CT scan as part of their routine work up. |
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| PH due to lung fibrosis (PH-LD-Fibr) | The patients with PH-LD-Fibr received an invasive right-heart catheterization and a thoracic CT scan as part of their routine work up. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Thoracic computed tomography | Radiation | Patients undergo contrast-enhanced thoracic computed tomography as part of their routine clinical work up. |
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| Measure | Description | Time Frame |
|---|---|---|
| Lung vessel morphology | Quantitative measures of lung vessel morphology based on automated CT image analysis based on artery-vein separation and vessel segmentation, which allow differentiation between the different groups of PH | 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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Populations are recruited from the patients visiting the outpatient clinic for pulmonology of the Medical University of Graz.
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| Name | Affiliation | Role |
|---|---|---|
| Horst Olschewski, MD | Medical University of Graz | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University Graz, Division of Pulmonology | Graz | Styria | 8010 | Austria |
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| ID | Term |
|---|---|
| D006976 | Hypertension, Pulmonary |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
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| PH due to combined emphysema and fibrosis (PH-LD-CPFE) | The patients with PH-LD-CPFE received an invasive right-heart catheterization and a thoracic CT scan as part of their routine work up. |
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| No PH | The patients without PH received an invasive right-heart catheterization and a thoracic CT scan as part of their routine work up. |
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| D002318 |
| Cardiovascular Diseases |