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Current diagnostic tools used in interstitial lung disease (ILD) do not meet the challenges set by the complex pathophysiology of this heterogenous group. The investigators therefore aimed to evaluate novel or not widely used diagnostic approaches for the detection and therapeutic monitoring of patients with various ILDs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| interstitial lung disease | patients with known or suspected ILD such as idiopathic pulmonary fibrosis, non-specific interstitial pneumonia, sarcoidosis, granulomatosis with polyangiitis |
| |
| pulmonary healthy controls | patients without known or suspected pulmonary disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| multiple breath washout tests | Device |
| ||
| impulse oscillometry |
| Measure | Description | Time Frame |
|---|---|---|
| lung clearance index (LCI) as determined by multiple breath washout | 30 minutes | |
| airway resistance and reactance (R5, X5, R-D5-20) as determined by impulse oscillometry | 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| repeatability of lung clearance index (LCI) | 30 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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patients with indication for routine lung function testing
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Frederik Trinkmann, Dr. | Contact | +496213833879 | frederik.trinkmann@umm.de |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universitätsmedizin Mannheim | Recruiting | Mannheim | Deutschland | 68167 | Germany |
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| Device |
|
| body plethysmography | Device |
|
| ID | Term |
|---|---|
| D017563 | Lung Diseases, Interstitial |
| D054990 | Idiopathic Pulmonary Fibrosis |
| D012507 | Sarcoidosis |
| D014890 | Granulomatosis with Polyangiitis |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D011658 | Pulmonary Fibrosis |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006968 | Hypersensitivity, Delayed |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D056648 | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis |
| D056647 | Systemic Vasculitis |
| D014657 | Vasculitis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D017445 | Skin Diseases, Vascular |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
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| ID | Term |
|---|---|
| D010993 | Plethysmography, Whole Body |
| ID | Term |
|---|---|
| D010991 | Plethysmography |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
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