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Current guideline-based criteria defining bronchial asthma do not always meet the challenges set by the complex pathophysiology of the disease. The investigators therefore aimed to evaluate novel or not widely used functional diagnostic approaches for the detection and therapeutic monitoring of patients with asthma.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| bronchial asthma | Patients with known or suspected asthma. |
| |
| pulmonary healthy controls | Patients without known or suspected pulmonary disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| impulse oscillometry | Diagnostic Test | impulse oscillometry |
|
| Measure | Description | Time Frame |
|---|---|---|
| Global ventilation heterogeneity | lung clearance index (LCI) derived from sulphur hexafluoride multiple breath washout | 30 minutes |
| Local ventilation heterogeneity | Sacin, Scond (Phase III slopes) derived from sulphur hexafluoride multiple breath washout | 30 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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patients with indication for routine lung function testing
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| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| ID | Term |
|---|---|
| D010993 | Plethysmography, Whole Body |
| ID | Term |
|---|---|
| D010991 | Plethysmography |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| multiple breath washout test | Diagnostic Test | multiple breath washout test |
|
| body plethysmography | Diagnostic Test | body plethysmography |
|
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |