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Current diagnostic tools used in pulmonary disease often do not meet the challenges set by the respective pathophysiology. The investigators therefore aimed to evaluate novel or not widely used diagnostic approaches for the detection and therapeutic monitoring of patients with various pulmonary diseases.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| pulmonary disease | patients with known or suspected pulmonary disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| multiple breath washout test (MBW) | Device |
| ||
| impulse oscillometry (IOS) |
| Measure | Description | Time Frame |
|---|---|---|
| correlation of lung clearance index (LCI) as determined by multiple breath washout with emphysema quantification as determined by qCT | 2 weeks | |
| correlation of airway resistance and reactance (R5, X5, R-D5-20) as determined by impulse oscillometry with emphysema quantification as determined by qCT | 2 weeks | |
| correlation of residual volume and airway resistance as determined by body plethysmography with and emphysema quantification as determined by qCT | 2 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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patients with indication for routine lung function testing and computed tomography
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Frederik Trinkmann, Dr. | Contact | +496213833879 | frederik.trinkmann@umm.de |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universitätsmedizin Mannheim | Recruiting | Mannheim | 68167 | Germany |
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| Device |
|
| body plethysmography (BP) | Device |
|
| quantitative computed tomography (qCT) | Device | ultra-low-dose qCT |
|
| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D001249 | Asthma |
| D017563 | Lung Diseases, Interstitial |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001982 | Bronchial Diseases |
| D012130 | Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| D010993 | Plethysmography, Whole Body |
| ID | Term |
|---|---|
| D010991 | Plethysmography |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
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