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Current guideline-based criteria defining COPD do not meet the challenges set by the complex pathophysiology of the disease. The investigators therefore aimed to evaluate novel or not widely used diagnostic approaches for the detection and therapeutic monitoring of COPD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COPD | Patients with known or suspected COPD Patients with known or suspected obstructive ventilation disorder |
| |
| pulmonary healthy controls | Patients without known or suspected pulmonary disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| impulse oscillometry | Device |
| ||
| multiple breath washout test |
| Measure | Description | Time Frame |
|---|---|---|
| lung clearance index (LCI) as determined by multiple breath washout | 30 minutes | |
| airway resistance and reactance (R5, X5, R-D5-20) as determined by impulse oscillometry | 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| repeatability of lung clearance index (LCI) | 30 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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patients with indication for routine lung function testing
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Frederik Trinkmann, Dr. | Contact | +496213833879 | frederik.trinkmann@umm.de |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Medical Center Mannheim | Recruiting | Mannheim | 68167 | Germany |
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| Device |
|
| body plethysmography | Device |
|
| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D011656 | Pulmonary Emphysema |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D010993 | Plethysmography, Whole Body |
| ID | Term |
|---|---|
| D010991 | Plethysmography |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
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