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The production of protein rich animal products is associated with a large environmental burden, and with ethical considerations. Additionally, the over-consumption of meat might be associated with detrimental effects to health.
Using mycoprotein, a food ingredient derived from the fermentation of a fungus, as a meat substitute could result in environmental benefits, and could have a role in managing obesity, diabetes and improving metabolic health. However, naturally produced mycoprotein has a high nucleotide content and little is known about the impact of nucleotides in uric acid levels and other health markers.
The aim of this study is to investigate the effect of a meal based on nucleotide rich mycoprotein on uric acid concentrations and other markers of health.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low nucleotide meal | Placebo Comparator | Mixed meal containing mycoprotein with a reduced nucleotide content (~ 2% nucleotides) |
|
| High nucleotide meal | Experimental | Mixed meal containing mycoprotein with a high nucleotide content (~ 10% nucleotides) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low nucleotide meal | Other | The participants will consume a mixed meal (sandwich) containing a nucleotide depleted mycoprotein product (low in nucleotides) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in serum uric acid concentrations over a 24 h period | Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal; 8, 12 and 24 hours after meal |
| Measure | Description | Time Frame |
|---|---|---|
| Blood glucose | Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal; 24 hours after meal | |
| Serum insulin | Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St Luke's Campus - University of Exeter | Exeter | Devon | EX1 2LU | United Kingdom |
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| High nucleotide meal | Other | The participants will consume a mixed meal (sandwich) containing a non nucleotide depleted mycoprotein product (high in nucleotides) |
|
| Branched chained amino-acids | Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal |