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| Name | Class |
|---|---|
| Quorn | INDUSTRY |
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Previous research has demonstrated that the food found in Quorn 'Mycoprotein' can lower the blood glucose response to a meal, which may be an important finding for the management of type 2 diabetes. However, it has never been investigated how this lower response occurs, and whether there is dose-dependent response with mycoprotein. The present study will include 12 healthy young adults, who will visit the laboratory for 3 test days, with each day lasting 9 hours. On each visit, separated by a washout period of at least 2 weeks, participants will ingest either a control drink with no mycoprotein, a drink containing 20g mycoprotein or a drink containing 40g mycoprotein. By intravenously infusing labelled glucose during each visit in combination with repeated blood sampling, investigators will determine if the lower blood glucose after mycoprotein ingestion is due to reduced glucose absorption from the gut or increased uptake into body tissues.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ingestion of 20g Mycoprotein Drink | Experimental | Milkshake containing 20g of mycoprotein, 250ml full-fat milk, 50g glucose and 11g lactose is given to participants in one dose |
|
| Ingestion of 40g Mycoprotein Drink | Experimental | Milkshake containing 40g of mycoprotein, 250ml full-fat milk, 50g glucose and 11g lactose is given to participants in one dose |
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| Ingestion of Isocaloric Control Drink | Placebo Comparator | Milkshake containing 250ml full-fat milk, 50g glucose, 19g dried skim milk and 9g full-fat dried milk |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mycoprotein Ingestion | Dietary Supplement | Ingestion of various doses of mycoprotein compared to placebo control |
|
| Measure | Description | Time Frame |
|---|---|---|
| Glucose absorption | How glucose is absorbed following the ingestion of a mycoprotein drink compared to a placebo control measured using the infusion of stable isotopes | 6 hours following ingestion of drink |
| Measure | Description | Time Frame |
|---|---|---|
| Incretin Hormones | Measurement of glucagon-like peptide-1(GLP-1) and gastric inhibitory polypeptide (GIP) in response to mycoprotein ingestion compared to placebo control | 6 hours following ingestion of drink |
| Insulinaemic Response |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Exeter | Exeter | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39003347 | Derived | Whelehan G, West S, Abdelrahman DR, Murton AJ, Finnigan TJA, Wall BT, Stephens FB. The addition of mycoprotein to a mixed-meal impacts postprandial glucose kinetics without altering blood glucose concentrations: a randomised controlled trial. Eur J Clin Nutr. 2024 Sep;78(9):757-764. doi: 10.1038/s41430-024-01470-4. Epub 2024 Jul 13. |
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Double blind crossover design
Measurement of insulin response following ingestion of drinks
| 6 hours following ingestion of drink |
| Production of Short-Chain Fatty Acids | Measurement of plasma acetate production in response to mycoprotein ingestion | 6 hours following ingestion of drink |
| Glucose Kinetics | Calculations using plasma deuterated glucose enrichment to determine rate of appearance of endogenous glucose, rate of disappearance of glucose and rate of appearance of exogenous glucose | 6 hours following ingestion of drink |