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Diet is the cornerstone treatment to manage blood sugar in people with Type 2 Diabetes (T2D). Fibres like guar gum and protein are macronutrients that have an effect in blood sugar levels. Mycoprotein is a fungi-based food high in both dietary fibre and protein shown to have a role in regulating blood sugar levels in healthy. However, little is known about the effects of mycoprotein on blood sugar levels in people with T2D. We are interested in South Asian because they have a different blood sugar response to the same food than a Caucasian.
The main aims of the study is to assess:
This is a double-blind crossover RCT. A total of 48 participants (24 Caucasian and 24 South Asian) with T2D and non insulin treated will be recruited. Participant will be randomly allocated to one of these two groups:
Group 1: Test food in form of soup and Group 2: Test food in form of mince. Once allocated in one of the groups, participant will consume in a random order 6 different test foods (soy, chicken, mycoprotein with and without guar gum) in a determined format (either as in soup or mince).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mycoprotein as in Soup | Experimental | 24 will be randomised to soup (12 caucasian and 12 south asian) in order to test raw mycoprotein. Test food will be administrated orally and allowed 15 minutes for consumption at an even pace. |
|
| Mycoprotein as in Mince | Experimental | 24 will be randomised to mince (12 caucasian and 12 south asian) in order to test processed mycoprotein (Quorn). Test food will be administrated orally and allowed 15 minutes for consumption at an even pace. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Test food containing different types of dietary protein | Other | The test foods will be (in six study visits): Soy mince/soup Chicken mince/soup Quorn mince/soup Soy mince/soup with guar gum Chicken mince/soup with guar gum Quorn mince/soup with guar gum |
| Measure | Description | Time Frame |
|---|---|---|
| Blood glucose | Fasting and Postprandial blood glucose | 180 minutes |
| Blood insulin | Fasting and Postprandial blood insulin | 180 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective appetite feelings | Measured using Visual Analogue Scale from 0 to 100 milimetres, being 100 milimetres the higher score. Questions assessed are:
For questions 1 to 4 the desirable outcome considered as "good result" for the test food mycoprotein are values less than 30 milimetres, and for questions 5 and 6, values above 60 milimetres. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gary Frost, PhD, RD | Contact | 020 7594 0959 | g.frost@imperial.ac.uk | |
| Anna Cherta Murillo, MRs | Contact | 07803076929 | ac6717@ic.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Gary Frost | Imperial College London | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| NIHR Imperial Clinical Research Facility | Recruiting | London | W12 0HS | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40410155 | Derived | Cherta-Murillo A, Zhou K, Tashkova M, Frampton J, Cepas de Oliveira AC, Ho C, Franco-Becker G, Chambers ES, Dornhorst A, Frost GS. Investigating the effects of mycoprotein and guar gum on postprandial glucose in type 2 diabetes: a double-blind randomised controlled trial. Nutr Diabetes. 2025 May 23;15(1):23. doi: 10.1038/s41387-025-00375-w. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 21, 2022 | |
| Reset | Sep 28, 2023 | |
| Release | Mar 22, 2024 | |
| Reset | Aug 21, 2024 | |
| Release | Mar 21, 2025 | |
| Reset | Apr 9, 2025 | |
| Release | Jun 2, 2025 | |
| Reset | Jun 17, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 21, 2022 | Sep 28, 2023 | |||
| Mar 22, 2024 |
| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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Double-Blind Crossover Randomised Controlled Trial
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| 180 minutes |
| Ad libitum energy intake | Measured using a buffet meal composed of wihte pasta with tomato sauce and weighting the serving bowl before and after to measure consumed grams of food. | At timepoint 180 minutes |
| Energy intake 72 hours post study visit | Energy intake of free-living subjects will be measured using self reported food diaries | For 3 days after study visit |
| Aug 21, 2024 |
| Mar 21, 2025 | Apr 9, 2025 |
| Jun 2, 2025 | Jun 17, 2025 |
| D004700 | Endocrine System Diseases |