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| Name | Class |
|---|---|
| Marlow Foods Ltd | UNKNOWN |
| NIHR Exeter Clinical Research Facility | NETWORK |
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In overweight individuals (BMI > 27.5 kg/m2), does daily consumption of mycoprotein containing Quorn Food products lower blood cholesterol compared with daily meat/fish consumption?
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Quorn Food products | Active Comparator |
| |
| Meat/fish products | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Quorn Foods products | Dietary Supplement | 180 g mycoprotein (wet weight; corresponding to 45 g dry weight) per day (equates to approx. 215 g Quorn Foods products, depending on the product) |
| Measure | Description | Time Frame |
|---|---|---|
| Postabsorptive blood cholesterol (free, total, LDL, HDL) concentrations | Test for intervention vs control differences in postabsorptive blood cholesterol levels (mMol) pre and post intervention | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Postprandial blood cholesterol concentration | Test for intervention vs control differences in postprandial blood cholesterol levels (mMol) pre and post intervention | 3 hours |
| Fingerprick blood glucose concentration |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Benjamin T Wall, PhD | University of Exeter | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Exeter | Exeter | Devon | EX1 2LU | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38306892 | Derived | Pavis GF, Iniesta RR, Roper H, Theobald HE, Derbyshire EJ, Finnigan TJA, Stephens FB, Wall BT. A four-week dietary intervention with mycoprotein-containing food products reduces serum cholesterol concentrations in community-dwelling, overweight adults: A randomised controlled trial. Clin Nutr. 2024 Mar;43(3):649-659. doi: 10.1016/j.clnu.2024.01.023. Epub 2024 Jan 24. |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| Meat/fish products | Dietary Supplement | Standard meat/fish products matched to Quorn group for protein intake |
|
Test for intervention vs control differences in blood glucose concentration (mMol) in postabsorptive and postprandial state
| 4 weeks |
| Satiety | Test for intervention vs control differences in satiety using a 10 centimetre 'Satiety Visual Analogue Scale' ratings, anchored by minimum to maximum response for a given aspect of satiety, where 0 cm is minimum and 10 cm is maximum | 4 weeks |
| Hedonic visual analogue scale | Test for intervention vs control differences and changes in hedonic response using 10 cm 'Hedonic Visual Analogue Scale' ratings, anchored by minimum to maximum response for a given aspect of hedonic response, where 0 cm is minimum and 10 cm is maximum | 4 weeks |
| Gastrointestinal side-effects | Test for intervention vs control differences in tolerance of diet | Once weekly, over 4 weeks |
| Fingerprick blood c-peptide | Test for intervention vs control differences in C-peptide concentration (ng/ml) in postabsorptive and postprandial state | 4 weeks |
| Fingerprick blood triglyceride concentration | Test for intervention vs control differences in blood triglyceride concentration (mMol) in postabsorptive and postprandial state | 4 weeks |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |