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Compare chronic (one week) of a 'normal' meat diet with one week of mycoprotein consumption, with or without a reduced nucleotide content, on markers of metabolic health, such as uric acid concentrations, blood glucose control and blood lipid profiles.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Animal protein based diet | Placebo Comparator | Seven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by animal products (meat and fish). |
|
| Low-nucleotide mycoprotein based diet | Active Comparator | Seven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by nucleotide-depleted mycoprotein products (commercial Quorn products). |
|
| High-nucleotide mycoprotein based diet | Active Comparator | Seven day fully controlled normocaloric diet (1.2 g/ kg body weight of protein per day), with the main protein source at the two main meals (lunch and dinner) being provided by nucleotide-rich mycoprotein products. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Animal protein based diet | Other |
| ||
| Low-nucleotide mycoprotein based diet |
| Measure | Description | Time Frame |
|---|---|---|
| Serum uric acid concentrations | Measured at baseline; days 2, 4 and 6 of the intervention; and after the 1 week intervention (day 8) |
| Measure | Description | Time Frame |
|---|---|---|
| Glycaemia and serum insulin - insulin sensitivity (oral glucose tolerance test) | Measured at baseline and after 1 week intervention (day 8) | |
| IL-6 | Measured at baseline and after 1 week intervention (day 8) |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35623844 | Derived | Coelho MOC, Monteyne AJ, Kamalanathan ID, Najdanovic-Visak V, Finnigan TJA, Stephens FB, Wall BT. High dietary nucleotide consumption for one week increases circulating uric acid concentrations but does not compromise metabolic health: A randomised controlled trial. Clin Nutr ESPEN. 2022 Jun;49:40-52. doi: 10.1016/j.clnesp.2022.04.022. Epub 2022 Apr 25. |
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| Other |
|
| High-nucleotide mycoprotein based diet | Other |
|
| 24 h blood glucose homeostasis - measured using a Dexcom CGMS | Measured 5 days at baseline (habitual data) and 5 days during the intervention (days 3 - 7) |
| Metabolomics (using Nuclear Magnetic Resonance - NMR) | Measured at baseline; days 2, 4 and 6 of the intervention; and after the 1 week intervention (day 8) |