Metabolic Effect of High-protein Meals in Men

Acute Metabolic Effect of the Protein Quality of a High-protein Meal Replacement in Healthy Men

The purpose of the clinical study is to investigate the effect of the protein quality of high-protein meal replacements on the management of post-prandial blood glucose in healthy men.

It was a double-blind, single center, randomized, crossover adaptive study design with 7 arms.

The subjects were submitted to 7 tests of ingestion of a high-protein meal replacement (test meal) in randomized order preferably a week apart. The 7 test meals were isocaloric, isonitrogenous and differed in their protein quality.

Inclusion Criteria:

• 20 - 50 years, male
• Healthy as determined by a medical questionnaire
• Normal weight: BMI 20 - 24.9 kg.m-2
• Normal fasting glycemia and insulinemia
• Normal fasting lipidemia (cholesterol and triglycerides)
• Normal liver function (transaminases, γ-GT) and kidney function (urea, creatinine)
• Capable of fast ingestion of the meal replacement (5-10 min)
• Having signed informed consent

Exclusion Criteria:

• Intestinal or metabolic diseases/disorders such as diabetic, renal, dyslipidemia, hepatic, hypertension, pancreatic or ulcer, including lacto-intolerance.
• Hypertension >150/95 mmHg
• Have had a gastrointestinal surgery
• Have a regular consumption of medication
• Vegetarian, vegan, under dietary supplements
• Have an alcohol intake: > 2 units a day or smoker
• Currently participating or having participated in a clinical trial during the last month
• Having given blood in the last month
• More than 5 x 45 min of intense exercise per week
• Volunteer who cannot be expected to comply with treatment