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The role of cAMP signaling mediated by beta2-adrenergic stimulation with agonists has been well-studied in skeletal muscles of animals. Studies in humans are scant and the scope of the present study is thus to investigate the role of cAMP signaling by beta2-adrenergic stimulation for muscle adaptations in humans.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Terbutaline | Experimental | Beta2-adrenergic stimulation with terbutaline |
|
| Placebo | Placebo Comparator | Placebo |
|
| Clenbuterol | Experimental | Beta2-adrenergic stimulation with clenbuterol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No training | Other |
| ||
| Endurance training |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle hypertrophy (lean body mass in Kilograms) | Lean body mass (kg) will be measured at two different days by Dual X-ray absorbance (DXA) | 2 days |
| Measure | Description | Time Frame |
|---|---|---|
| Energy turnover (ml/min or mmol/kg dry weight muscle) | Pulmonary gas exchange and lactate and glycogen will be measured in muscle biopsies obtained before and after intense exercise | 1 day |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Morten Hostrup, PhD | Contact | +4524474785 | mortenhostrup@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Nutrition, Exercise and Sports | Recruiting | Copenhagen | 2100 | Denmark |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Mar 24, 2020 | |
| Reset | Apr 6, 2020 | |
| Release | Oct 11, 2021 | |
| Reset | Nov 8, 2021 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Mar 24, 2020 | Apr 6, 2020 | |||
| Oct 11, 2021 |
| ID | Term |
|---|---|
| D000076663 | Endurance Training |
| D055070 | Resistance Training |
| D013726 | Terbutaline |
| D002976 | Clenbuterol |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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| Other |
|
| Resistance Training | Other |
|
| Terbutaline | Drug |
|
| Clenbuterol | Drug |
|
| Placebo | Drug |
|
| Bispebjerg University Hospital | Recruiting | Copenhagen | 2400 | Denmark |
|
| Nov 8, 2021 |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D000588 | Amines |