cAMP Signaling and Muscle Adaptations

The role of cAMP signaling mediated by beta2-adrenergic stimulation with agonists has been well-studied in skeletal muscles of animals. Studies in humans are scant and the scope of the present study is thus to investigate the role of cAMP signaling by beta2-adrenergic stimulation for muscle adaptations in humans.

Inclusion Criteria:

• healthy young men
• 18-35 years of age
• Informed consent
• Active 2-5 hours of training pr. week
• Maximal oxygen uptake (ml/min/kg) of 40-60
• Lean body mass of 55-65 kg / Lean mass index 14-22 kg/m2

Exclusion Criteria:

• Smoker
• Allergy towards study drugs
• Chronic disease