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The purpose of the project is to investigate the effect of amino acid availability on the muscle anabolic response to beta2-adrenergic stimulation in young healthy men and women.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Salmeterol + amino acid availability | Experimental | The participants will be administered salmeterol from an inhaler device and amino acid availability (protein powder in a shaker) daily during a 6-week intervention. |
|
| Salmeterol + placebo | Experimental | The participants will be administered salmeterol from an inhaler device. Furthermore they will be administered placebo (carbo fuel in a shaker) daily during a 6-week intervention. | |
| Placebo + placebo | Placebo Comparator | The participants will be administered placebo from an inhaler device. Furthermore they will be administered placebo (carbo fuel in a shaker) daily during a 6-week intervention. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Salmeterol + amino acid availability | Drug | The participants will be administered 200 µg salmeterol (8 puffs) from a MDI device and 40 g amino acid availability (clear whey in a shaker with water) daily during a 6-week intervention. Participants will be instructed to provide documentation of both the inhalation and the shaker intake via video. |
| Measure | Description | Time Frame |
|---|---|---|
| Skeletal muscle hypertrophy | Muscle hypertrophy measured using Dual-energy X-ray Absorptiometry (DXA). | Through study completion, an average on 7 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Quadriceps strength | Maksimal torque (Nm) achieved during isometric contraction | Through study completion, an average on 7 weeks |
| Power output during sprint testing | Power output measured in Watts during a sprint on a bike ergometer |
| Measure | Description | Time Frame |
|---|---|---|
| Maximal oxygen uptake | Maximal oxygen uptake measured during an incremental test to exhaustion on a bike ergometer. | Through study completion, an average on 7 weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| August Krogh Building | Recruiting | Copenhagen | 2100 | Denmark |
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| ID | Term |
|---|---|
| D000068299 | Salmeterol Xinafoate |
| ID | Term |
|---|---|
| D000420 | Albuterol |
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 |
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Thirty-six healthy, well-trained men and women will be randomized into three distinct groups, each receiving one of the following interventions: 1) salmeterol with amino acid availability, 2) salmeterol, or 3) a placebo, administered twice daily over a 6-week intervention period. This design aims to elucidate the impact of amino acid availability on the muscle anabolic response to beta2-adrenergic stimulation.
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|
| Salmeterol + placebo | Drug | The participants will be administered 200 µg salmeterol (8 puffs) from a MDI device. Furthermore they will be administered 80 g placebo (carbo fuel in a shaker with water) daily during a 6-week intervention. Participants will be instructed to provide documentation of both the inhalation and the shaker intake via video. |
| Placebo + placebo | Drug | The participants will be administered placebo (8 puffs) from a MDI device. Furthermore they will be administered 80 g placebo (carbo fuel in a shaker with water) daily during a 6-week intervention. Participants will be instructed to provide documentation of both the inhalation and the shaker intake via video. |
|
| Through study completion, an average on 7 weeks |
| Power output during time trial | Mean power output measured in Watts during a time trial on a bike ergometer | Through study completion, an average on 7 weeks |
| Organic Chemicals |
| D000588 | Amines |
| D010627 | Phenethylamines |
| D005021 | Ethylamines |