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The scope of the study is to investigate the physiological response to salbutamol and exercise. A particular focus is on the metabolic response and amine metabolism.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| beta2-agonist and exercise | Active Comparator | Subjects undergo exercise training with administration of salbutamol (800 microgram in 12 hours x 2) |
|
| placebo and exercise | Sham Comparator | Subjects undergo exercise training with administration of sham placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| salbutamol | Drug | subjects ingest salbutamol |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Body composition | Change in body composition (measured by dual energy x ray absorptiometry) | Baseline, 2 weeks, 4 weeks and 6 weeks |
| Maximal oxygen consumption (VO2max) | Change in VO2max (measured during bike ergometer cycling to exhaustion) | Baseline, 2 weeks, 4 weeks and 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Salbutamol urine concentration | Concentration of salbutamol in urine | Before (baseline) as well as 0-1 hours, 1-2 hours, 2-4 hours, 4-8 hours, and 8-16 hours after administration |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle strength | Isometric muscle force of the quadriceps | Baseline, 2 weeks, 4 weeks and 6 weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| August Krogh Building | Recruiting | Copenhagen | Denmark |
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| ID | Term |
|---|---|
| D000420 | Albuterol |
| D015444 | Exercise |
| ID | Term |
|---|---|
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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| exercise |
| Other |
subjects undergo 6 weeks of endurance training (3 times weekly) |
|
| D000588 |
| Amines |
| D010627 | Phenethylamines |
| D005021 | Ethylamines |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |