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| Name | Class |
|---|---|
| World Anti-Doping Agency | OTHER |
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Athletes using asthma medications called β2-agonists win a disproportionately high number of medals at Olympic Games. Due to a large variety in the genes that affect how individuals respond to β2-agonists, the investigators will look at variations in the genetic response to these medications by dividing athletes into high-responders and low-responders. The investigators will then compare athletic performance after the inhalation of β2-agonists to placebo. Furthermore, the investigators will analyze the effect of β2-agonists on breathing mechanics. Due to differences in their anatomy females may decrease the energy needed for breathing during high-intensity exercise to a greater extent compared to male athletes after the inhalation of β2-agonists.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Salbutamol | Experimental | 400ug of salbutamol (one single inhalation) will be inhaled 60min prior to the begin of a time trial. Mean power output during the following 10km time trial will be described to 1600ug salbutamol and placebo. |
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| Placebo | Placebo Comparator | 400ug of placebo (one single inhalation) will be inhaled 60min prior to the begin of a time trial. Mean power output during the following 10km time trial will be described to 400ug and 1600ug salbutamol. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Salbutamol | Drug | 60 minutes prior to the start of a 10km cycling time trial on a bike ergometer, subjects will inhale either 400ug of salbutamol 1600ug of salbutamol or 400ug of placebo in a randomly assigned manner in a single dose. |
| Measure | Description | Time Frame |
|---|---|---|
| The effect of inhaled salbutamol on mean power output during cycling performance in female and male athletes | Athletes perform a two time trials, each on a separate day. The time trials are performed 60min after the inhalation of salbutamol or placebo. | Mean power output is assessed over the duration of a 10km time trial (start of time trial until completion of time trial) on a bike ergometer. |
| The effect of inhaled salbutamol on work of breathing (WOB) and expiratory flow limitation (EFL) in female and male athletes | EFL and WOB will be assessed with the help of an esophageal balloon and mouth pressure. | WOB and EFL will be assessed during an incremental exercise test. Exercise will start at 0 Watts and will then be increased every 2.5min by 30 Watts until maximal exertion. |
| Measure | Description | Time Frame |
|---|---|---|
| The effect of inhaled salbutamol on minute ventilation in asthmatic and non-asthmatic trained, female and male cyclists | Minute ventilation will be assessed during two 10km time trials (one time trial will be started 60min after the inhalation of salbutamol, the second time trial will be started 60min after the inhalation of placebo). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michael S Koehle, MD, PhD | University of British Columbia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Environmental Physiology Laboratory, University of British Columbia | Vancouver | British Columbia | V6T 1Z1 | Canada |
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| ID | Term |
|---|---|
| D000420 | Albuterol |
| ID | Term |
|---|---|
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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| Placebo | Drug |
|
| D000588 |
| Amines |
| D010627 | Phenethylamines |
| D005021 | Ethylamines |