Salbutamol Use in Ozone Air Pollution by People With Asthma and/or Exercise Induced Bronchoconstriction (EIB)

Examining the Effect of Salbutamol Use in Asthma and/or Exercise Induced Bronchoconstriction Whilst Exercising in Ozone Air Pollution

Salbutamol use is increased in areas with high levels of ozone pollution and the potential consequences of this are not well known. The purpose of this study is to examine the effect of salbutamol on lung function and inflammation in people with asthma and/or EIB exercising in ozone air pollution. To examine this, we are planning a randomized cross over trial where people with asthma and/or EIB complete sub maximal exercise in four conditions on four separate days. The four condition are: ozone + salbutamol, filtered air + salbutamol, ozone + placebo medication, and filtered air + placebo medication.

Inclusion Criteria:

• Have asthma and/or EIB
• Able to perform maximal exercise
• Able to communicate sufficiently using the English language

Exclusion Criteria:

• Allergic to salbutamol (also known as Ventolin)
• Pregnant or potentially pregnant
• Have a history of smoking
• Had an upper respiratory tract infection within the last 4 weeks
• Have a chronic respiratory disease other than asthma or EIB