Adaptation to Ozone in Individuals With Asthma/Exercise-induced Bronchoconstriction

Pulmonary and Vascular Adaptations to a 5-days Exercise Protocol in Ozone in Physically Active Individuals With Asthma and Exercise-induced Bronchoconstriction

Researchers found that impairments in the cardiopulmonary system caused by acute exposure to ozone were outweighed by repeated exposures to ozone. The goal of this study is to confirm there will be an adaptation similar to what was previously proved but in individuals with asthma and exercise-induced bronchoconstriction (EIB). The purpose is to examine adaptive responses in a randomized cross-over trial in which physically active individuals will perform submaximal exercise on five days in ozone and filtered air exposures separated by a washout period.

Inclusion Criteria:

• Recreationally active individuals
• Diagnosed asthma and/or mild exercise-induced bronchoconstriction: defined by an FEV1 fall equal to or greater than 10% but lower than 25% in the eucapnic hyperventilatory test.
• Able to securely perform a maximal exercise test (responded 'no' to all questions on the PAR-Q+ questionnaire)
• Able to communicate in English

Exclusion Criteria:

• Diagnosed with any cardiorespiratory or vascular diseases
• Pregnant or potentially pregnant
• Non-smoking
• Lower limb musculoskeletal injury or lower limb limitation to cycle on a bicycle ergometer
• Recent respiratory symptoms or upper tract infection within 4 weeks
• On vitamin (e.g., C or E) supplementation