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Researchers found that impairments in the cardiopulmonary system caused by acute exposure to ozone were outweighed by repeated exposures to ozone. The goal of this study is to confirm there will be an adaptation similar to what was previously proved but in individuals with asthma and exercise-induced bronchoconstriction (EIB). The purpose is to examine adaptive responses in a randomized cross-over trial in which physically active individuals will perform submaximal exercise on five days in ozone and filtered air exposures separated by a washout period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ozone (O3) group | Experimental | Participants of the experimental group will perform sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer while inhaling 170ppb ozone delivered continuously during each exercise session. |
|
| Filtered Air | Sham Comparator | Participants of the sham group will also perform sub-maximal exercise (60% of VO2max for 30 minutes) on a cycle ergometer similar to intervention. However, only in this group, the ozone generator will not be activated so that just filtered air will be delivered to the participant while performing each exercise session. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Behavioral | Cycling at 60% of VO2max on a cycle ergometer for 30 minutes |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in FEV1 from baseline to 10 minutes after exercise | Measurement of pulmonary function: forced exhaled volume in the first second (FEV1) in liters | Measured at baseline and 10 minutes after each exercise bout |
| Change in FVC from baseline to 10 minutes after exercise | Measurement of pulmonary function: forced vital capacity (FVC) in liters | Measured at baseline and 10 minutes after each exercise bout |
| Change in FEF25-75 from baseline to 10 minutes after exercise | Measurement of pulmonary function: forced expiratory flow at 25-75% of pulmonary volume in liters per second (L/s) | Measured at baseline and 10 minutes after each exercise bout |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Pulse Wave Velocity (PWV) from baseline to 20 minutes after exercise | Velocity (in meters per second) at which the blood pressure pulse propagates through set points in the circulatory system | Measured at baseline and 20 minutes after each exercise bout |
| Change in Fraction of exhaled nitric oxide (FeNO) from baseline to 5 minutes after exercise |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Patric O Gonçalves, BScPT | Contact | 6048229331 | patricog@alumni.ubc.ca | |
| Michael Koehle | Contact | michael.koehle@icloud.com |
| Name | Affiliation | Role |
|---|---|---|
| Michael Koehle, MD PhD | Professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Environmental Physiology Laboratory | Recruiting | Vancouver | British Columbia | V6T 1Z1 | Canada |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 27, 2023 | |
| Reset | May 10, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 27, 2023 | May 10, 2024 |
| ID | Term |
|---|---|
| D001249 | Asthma |
| D001250 | Asthma, Exercise-Induced |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D010126 | Ozone |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Air quality condition (Ozone and filtered air) will be double-blinded; Participants will not be told at any time before the study completion to which group they are assigned (intervention or sham)
| Ozone | Other | Breathing 170ppb ozone |
|
| Filtere Air | Other | Breathing filtered air |
|
Non-invasive airway inflammation biomarker (in part per billion, ppb) |
| Measured at baseline and 5 minutes after each exercise bout |
| University of British Columbia | Recruiting | Vancouver | British Columbia | V6T 1Z3 | Canada |
|
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D000092202 | Exercise-Induced Allergies |
| D010100 | Oxygen |
| D005740 | Gases |
| D007287 | Inorganic Chemicals |