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| Name | Class |
|---|---|
| Canadian Academy of Sport and Exercise Medicine (CASEM) | UNKNOWN |
| Natural Sciences and Engineering Research Council, Canada | OTHER |
| Fraser Basin Council | UNKNOWN |
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When exposed to air pollution, the asthma symptoms are aggravated and lung function is impaired. Due to high breathing rates and volumes, physically active individuals are at particular risk of lung health impairment due to the high breathing rates and volumes. Greater doses of air pollutants reach deeper areas in the lungs where they can trigger asthma-symptoms. When treating these symptoms with inhaled beta-2-agonists the airways widen even more, allowing the air pollutants to reach even deeper areas of the lung. With this study the investigators investigate how inhaled beta-2-agonists affect athletic capacity and lung health in physically active asthmatics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Resting in diesel exhaust following salbutamol inhalation | Active Comparator | Participants will be sitting in an air pollution chamber while being exposed to diesel exhaust (PM2.5 of 300 μg/m3) for a total of 1hour following the inhalation of 400ug of salbutamol. |
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| Resting in diesel exhaust following placebo inhalation | Placebo Comparator | Participants will be sitting in an air pollution chamber while being exposed to diesel exhaust (PM2.5 of 300 μg/m3) for a total of 1hour following the inhalation of a placebo. |
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| Cycling in diesel exhaust following salbutamol inhalation | Active Comparator | Participants will be cycling while being exposed to diesel exhaust (PM2.5 of 300 μg/m3) for a total of 1 hr following the inhalation of 400ug of salbutamol. |
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| Cycling in diesel exhaust following placebo inhalation | Placebo Comparator | Participants will be cycling while being exposed to diesel exhaust (PM2.5 of 300 μg/m3) for a total of 1 hr following the inhalation of a placebo |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rest (Sitting on chair) | Other | Study participants will sit on a chair for 60min. This is to simulate physical resting condition. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in rating of perceived exertion for breathing, dyspnea | Difference in perceived dyspnea between salbutamol and placebo exposure as well as polluted air and filtered air. Dyspnea ratings will be collected every 2.5min for a duration of 45min during the exercise test. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in work of breathing (WOB) between filtered air and polluted air | work of breathing will be assessed every 2.5min for a time period of 45min during the exercise bout |
| Measure | Description | Time Frame |
|---|---|---|
| Change in spirometry (FEV1 and FVC) between filtered air and polluted air | Spirometry will be assessed at baseline and 45min after the start of the exercise bout. | |
| Change in cognitive function | cognitive function will be assessed using the NIH toolbox tests and the brain derived neurotrophic factor (BDNF) blood serum measurements |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Michael S Koehle, MD, PhD | University of British Columbia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of British Columbia, Environmental Physiology Laboratory | Vancouver | British Columbia | V6T 1Z1 | Canada |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| C092779 | RE1-silencing transcription factor |
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| Resting in filtered air following salbutamol inhalation | Sham Comparator | Participants will be sitting while being exposed to filtered air for a total of 1hour following the inhalation of 400ug of salbutamol. |
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| Resting in filtered air following placebo inhalation | Placebo Comparator | Participants will be sitting while being exposed to filtered air for a total of 1hour following the inhalation of a placebo. |
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| Cycling in filtered air following salbutamol inhalation | Sham Comparator | Participants will be cycling while being exposed to filtered air for a total of 1 hr following the inhalation of 400ug of salbutamol. |
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| Cycling in filtered air following placebo inhalation | Placebo Comparator | Participants will be cycling while being exposed to filtered air for a total of 1 hr following the inhalation of a placebo |
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| Cycling exercise | Other | Study participants will exercise on a cycle ergometer for 45min. Participants will start their 30-min long constant workload exercise test test 60-min after the drug intervention. The exercise test will be set to a resistance of 50% of the maximal wattage that was reached on the graded exercise test on the screening day. The cycling exercise intervention will follow the rest-intervention. |
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| Salbutamol inhalation | Drug | Study participants will be exposed to 400ug of salbutamol prior to entering the air pollution chamber. |
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| Placebo inhalation | Drug | Study participants will inhale a placebo (placebo for salbutamol) prior to entering the air pollution chamber |
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| Diesel Exhaust Exposure | Other | Participants will be exposed to PM2.5 of 300 μg/m3 |
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| Filtered air | Other | Participants will be breathing filtered air |
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| Cognitive function will be assessed at baseline (prior to entering the air pollution chamber) and 45 min after the start of the exercise intervention. |
| Retinal Imaging | The blood vessels in the eye will be imaged using a camera. | The retina will be imaged at baseline (prior to entering the air pollution chamber) and 20 min after the completion of the exercise intervention. |