Chronic Beta2-adrenergic Stimulation and Cardiac and Skeletal Muscle Hypertrophy

Role of 11 Weeks of Beta2-adrenergic Signaling and Resistance Training for Cardiac and Skeletal Muscle Hypertrophy in Men

Studies in animals have shown that beta2-adrenoceptor activation with selective agonists regulates protein metabolism and muscle growth in skeletal and cardiac muscle tissue. These effects may be mediated by cAMP/PKA dependent activation of several downstream sites that modulate protein synthesis and breakdown. While the role of beta2-adrenoceptor signaling is well-described in animals, it is inadequately explored in humans. The purpose of the study is thus to investigate the effect of chronic beta2-adrenergic stimulation (cAMP/PKA-signaling) on muscle hypertrophy.

Inclusion Criteria:

• Physical active
• Non-smokers
• Non-asthmatics
• No chronic diseases
• Informed consent

Exclusion Criteria:

• Smoker
• Allergy towards study drug