Beta2-adrenergic Agonism and Muscle Remodelling

Gender-specific Role of the beta2-adrenergic Stimulation With Short- or Long-acting Selective Agonist in Relation to Muscle Remodelling, Function, Performance, and Anti-doping

The study aims to investigate gender-specific adaptations to beta2-adrenoceptor stimulation with selective short- and long-acting beta2-agonist with emphasis on skeletal muscle in relation to performance enhancing effects and anti-doping

Inclusion Criteria:

• Healthy men and women, aged 18-45 years
• VO2max >55 ml/kg/min for men and >50 ml/kg/min for women (± biologic and techinical variation of 5.6% (Katch et al. 1982)
• Body Mass Index (BMI) < 26

Exclusion Criteria:

• Chronic user of beta2-agonist or allergy towards study drugs
• Serious adverse side effects of the used study drug
• Chronic disease that by the project physician would affect any of the outcomes of the study
• Smoker
• Chronic use of prescription medication (other than contraceptives for women)
• Pregnancy