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The purpose of the project is investigate muscle memory and underlying mechanisms in humans following resistance training and use of the anabolic substance clenbuterol.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Clenbuterol | Experimental | Participants are randomized to daily ingestion of clenbuterol for a period of 8 weeks, with or without supervised resistance training. |
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| Placebo | Placebo Comparator | Participants are randomized to daily ingestion of placebo for a period of 8 weeks, with or without supervised resistance training. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Clenbuterol | Drug | Participants ingest 80 micrograms clenbuterol daily during the initial 8-week period. This period is followed by a washout of 16 weeks with no drug and resistance training. Thereafter, an 8-week period with supervised resistance training is commenced, with no drug. |
| Measure | Description | Time Frame |
|---|---|---|
| Fiber cross-sectional area | Immunohistochemistry to determine fiber cross-sectional area | The change in fiber cross-sectional is assessed at baseline, 8, 24 and 32 weeks |
| Myonuclei | Immunohistochemistry to determine number of myonuclei | The change in myonuclei is assessed at baseline, 8, 24 and 32 weeks |
| Skeletal muscle proteome | Pathway enrichment analysis of the muscle proteome using mass-spectrometry based proteomics | The change in the muscle proteome is assessed at baseline, 8, 24 and 32 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Lean mass | Lean mass assessed by dual X-ray absorptiometry (DXA) | The change in lean mass is assessed at baseline, 8, 24 and 32 weeks |
| Isometric muscle strength | Maximal voluntary isometric contraction of m. quadriceps |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Morten Hostrup | Contact | +4535321595 | mhostrup@nexs.ku.dk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| August Krogh Building | Recruiting | Copenhagen | 2100 | Denmark |
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| ID | Term |
|---|---|
| D002976 | Clenbuterol |
| ID | Term |
|---|---|
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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|
| Placebo | Drug | Participants ingest placebo tablets daily during the initial 8-week period. This period is followed by a washout of 16 weeks with no drug and resistance training. Thereafter, an 8-week period with supervised resistance training is commenced, with no drug. |
|
| The change in maximal voluntary isometric contraction is assessed at baseline, 8, 24 and 32 weeks |
| Dynamic muscle strength | 1-repetition maximum | The change in 1-repetition maximum is assessed at baseline, 8, 24 and 32 weeks |
| Sprint performance | Work performed (W) during a sprint on a bicycle ergometer | The change in sprint performance is assessed at baseline, 8, 24 and 32 weeks |
| Satellite cells | Immunohistochemistry to determine number of satellite cells | The change in satellite cells is assessed at baseline, 8, 24 and 32 weeks |
| D000588 |
| Amines |