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The purpose of this project is to investigate underlying mechanisms of testosterone- and resistance training-induced muscle hypertrophy and muscle memory in humans.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Testosterone | Experimental | Participants are randomized to a single injection of 1000 mg testosterone undecanoate |
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| Placebo | Placebo Comparator | Participants are randomized to a single placebo injection |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Testosterone Undecanoate | Drug | Following testosterone/placebo injection, participants undergo supervised resistance training for 4 weeks. This period is followed by a washout period with no drug and either continued resistance training or detraining for 16 weeks. Thereafter, another 4-week period with supervised resistance training is commenced, with no drug. |
| Measure | Description | Time Frame |
|---|---|---|
| Fiber cross-sectional area | Immunohistochemistry to determine fiber cross-sectional area | The change in fiber cross-sectional is assessed at baseline, 4, 20 and 24 weeks |
| Myonuclei | Immunohistochemistry to determine number of myonuclei | The change in myonuclei is assessed at baseline, 4, 20 and 24 weeks |
| Skeletal muscle proteome | Pathway enrichment analysis of the muscle proteome using mass spectrometry-based proteomics | The change in the muscle proteome is assessed at baseline, 4, 20 and 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Lean mass | Lean mass assessed by dual X-ray absorptiometry (DXA) | The change in lean mass is assessed at baseline, 4, 20 and 24 weeks |
| Satellite cells | Immunohistochemistry to determine number of satellite cells |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lukas Moesgaard | Contact | +4561724440 | lm@nexs.ku.dk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen | Recruiting | Copenhagen | 2100 | Denmark |
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| ID | Term |
|---|---|
| C010792 | testosterone undecanoate |
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| The change in satellite cells is assessed at baseline, 4, 20 and 24 weeks |
| Muscle strength | 1-repetition maximum | The change in 1-repetition maximum is assessed at baseline, 4, 20 and 24 weeks |