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The purpose of the project is to investigate the proteome signature dynamics and remodelling in human skeletal muscle induced by exercise training
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Endurance | Experimental | Endurance training |
|
| Resistance | Experimental | Resistance training |
|
| Sprint | Experimental | Sprint training |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endurance training | Other | Subjects perform a period of endurance training |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Skeletal muscle proteome signature | Pathway enrichment analysis of the muscle proteome | Change from baseline at week 6 or 8 depending on the intervention |
| Anabolic signaling | Western blotting of proteins related to anabolic signaling | Change in anabolic signaling from rest to 1 hour following resistance exercise both at baseline and following 8 weeks of resistance training |
| Measure | Description | Time Frame |
|---|---|---|
| Skeletal muscle mitochondrial respiration | High resolution respirometry | Change from baseline at week 6 following endurance and sprint training |
| Maximal oxygen consumption | VO2max during incremental exercise |
| Measure | Description | Time Frame |
|---|---|---|
| Skeletal muscle mitochondrial supercomplexes | Pathway enrichment analysis of mitochondrial supercomplexes | Change from baseline at week 6 following endurance and sprint training |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| August Krogh Building | Copenhagen | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40818533 | Derived | Kissow J, Jacobsen KJ, Jessen S, Thomsen LB, Quesada JP, Bangsbo J, Deshmukh AS, Hostrup M. Global Proteomics Reveals Distinct Muscle Adaptations to Menstrual Cycle Phase-Based Sprint Interval Training in Endurance-Trained Females. Mol Cell Proteomics. 2025 Oct;24(10):101053. doi: 10.1016/j.mcpro.2025.101053. Epub 2025 Aug 14. |
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| ID | Term |
|---|---|
| D000076663 | Endurance Training |
| D055070 | Resistance Training |
| D000072696 | High-Intensity Interval Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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| Resistance training |
| Other |
Subjects perform a period of resistance training |
|
| Sprint training | Other | Subjects perform a period of sprint training |
|
| Change from baseline at week 6 following endurance and sprint training |
| Body composition | Lean and fat mass during dual X-ray absorptiometry | Change from baseline at week 6 or 8 depending on the intervention |
| Myonuclei | Immunohistochemistry to determine number of myonuclei | Change from baseline at week 8 following resistance training |
| Satellite cells | Immunohistochemistry to determine number of satellite cells | Change from baseline at week 8 following resistance training |
| Fiber size | Immunohistochemistry to determine fiber size | Change from baseline at week 8 following resistance training |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |