Effect of Exercise on Muscle Proteome Signature

Effect of Exercise Training on Skeletal Muscle Proteome Signature of Young Men

The aim of the study is to investigate skeletal muscle proteome signature changes induced by exercise training in young men

Advances in omics technologies have allowed for the identification of biomarkers with importance for the beneficial adaptations imposed by exercise training. Skeletal muscle exhibits remarkable plasticity to exercise training, as illustrated by pronounced alterations to the proteomic landscape, such as mitochondrial biogenesis. However, despite recent advances that have helped describe the proteomic landscape in response to a period of exercise training, our understanding of the processes pertaining to post-translation modification is scant. In this study, we aim to investigate the human acetylome and proteome in response to exercise training.

Inclusion Criteria:

• Healthy
• VO2max of 45-55 ml/kg/min (+/- SD) / 3000-4000 ml/min (+/- SD)
• Body mass index (BMI) of 19-26 kg/m2
• Normal ECG (electrocardiography)

Exclusion Criteria:

• Serious adverse effects to exercise
• Chronic disease