Effect of Exercise on Muscle Proteome Signature | NCT03270475

Studies
Effect of Exercise on Muscle Proteome Signature

NCT03270475

Sponsor

Morten Hostrup, PhD

Status

Completed

Last Update Posted

Jan 15, 2021Actual

Enrollment

8Actual

Phase

Not Applicable

Conditions

Healthy

Interventions

exercise training

Countries

Denmark

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Jan 2021

Overall Recruitment Status or Expanded Access Status

Completed

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Aug 28, 2017Actual

Primary Completion Date

Oct 15, 2017Actual

Completion Date

Oct 15, 2017Actual

First Submitted Date

Aug 28, 2017

First Submission Date that Met QC Criteria

Aug 29, 2017

First Posted Date

Sep 1, 2017Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Jan 12, 2021

Last Update Posted Date

Jan 15, 2021Actual

Oversight Module

Has Data Monitoring Committee (DMC)

Yes

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Not provided

FDAAA801 Violation

Not provided

Description Module

Brief Summary

The aim of the study is to investigate skeletal muscle proteome signature changes induced by exercise training in young men

Detailed Description

Advances in omics technologies have allowed for the identification of biomarkers with importance for the beneficial adaptations imposed by exercise training. Skeletal muscle exhibits remarkable plasticity to exercise training, as illustrated by pronounced alterations to the proteomic landscape, such as mitochondrial biogenesis. However, despite recent advances that have helped describe the proteomic landscape in response to a period of exercise training, our understanding of the processes pertaining to post-translation modification is scant. In this study, we aim to investigate the human acetylome and proteome in response to exercise training.

Design Module

Study Type

Interventional

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Not provided

Target Follow-Up Duration

Not provided

Phases

Not Applicable

Interventional Study Design

Allocation

Biospecimen

No data available

No data is available for this block.

Enrollment

8Actual

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Exercise	Experimental	12-15 training sessions of 30 min over 4-5 weeks	Other: exercise training

Interventions

Name	Type	Description	Arm Group Labels	Other Names
exercise training	Other	subjects complete 4-5 weeks of training	Exercise

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Skeletal muscle proteome signature	proteomics	Change from baseline proteome signature at 5 weeks

Secondary Outcomes

Not provided

Other Outcomes

Measure	Description	Time Frame
Skeletal muscle acetylome signature	acetylomics	Change from baseline acetylome signature at 5 weeks
Skeletal muscle mitochondrial respiration	Mitochondrial respiratory capacity

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Healthy
VO2max of 45-55 ml/kg/min (+/- SD) / 3000-4000 ml/min (+/- SD)
Body mass index (BMI) of 19-26 kg/m2
Normal ECG (electrocardiography)

Exclusion Criteria:

Serious adverse effects to exercise
Chronic disease

Accepts Healthy Volunteers

Yes

Sex

Male

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

40 Years

Standard Ages

Adult

Study Population

Not provided

Sampling Method

Not provided

Contacts/Locations Module

Central Contacts

Not provided

Overall Officials

Not provided

Locations

Facility	Status	City	State	ZIP	Country	Contacts
Department of Nutrition, Exercise and Sports		Copenhagen		2100	Denmark

IPD Sharing Statement Module

Plan to Share IPD

Undecided

Description

Not provided

Types

Not provided

Time Frame

Not provided

Access Criteria

Not provided

URL

Not provided

Intervention Browse Module

MeSH Terms

ID	Term
D015444	Exercise

Ancestor Terms

ID	Term
D009043	Motor Activity
D009068	Movement
D009142	Musculoskeletal Physiological Phenomena
D055687	Musculoskeletal and Neural Physiological Phenomena

Browse Leaves

Not provided

Browse Branches

Not provided