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The experimental model is a semi-acute, over-night, study where the purpose is to evaluate food factors related to colonially derived regulation and satiety in healthy subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| + ind. CHO | Experimental | Test meals: intake of high levels of indigestible carbohydrates the evening prior to measurements of variables |
|
| - ind. CHO | Experimental | Reference meal: scarce intake of indigestible carbohydrates the evening prior to measurements of variables |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High levels of indigestible carbohydrates | Other |
| ||
| Low levels of indigestible carbohydrates |
| Measure | Description | Time Frame |
|---|---|---|
| Blood Glucose, levels of glucose in blood | Postprandial 0-180 min after breakfast | |
| Insulin, levels of insulin in blood | Postprandial 0-180 min after breakfast | |
| Appetite hormones, levels of Peptide YY (PYY) in blood | Postprandial 0-180 min after breakfast | |
| Markers of colonic fermentation, levels of hydrogen in breath | Postprandial 0-180 min after breakfast | |
| Inflammation markers, levels of Interleukin-6 (IL-6) in blood | Postprandial 0-180 min after breakfast |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective satiety, as measured by VAS | Postprandial 0-180 min after breakfast |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anne Nilsson, PhD | Lund University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medicon Village | Lund | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29338758 | Derived | Gyll J, Ridell K, Ohlund I, Karlsland Akeson P, Johansson I, Lif Holgerson P. Vitamin D status and dental caries in healthy Swedish children. Nutr J. 2018 Jan 16;17(1):11. doi: 10.1186/s12937-018-0318-1. | |
| 28431559 | Derived | Sandberg JC, Bjorck IME, Nilsson AC. Effects of whole grain rye, with and without resistant starch type 2 supplementation, on glucose tolerance, gut hormones, inflammation and appetite regulation in an 11-14.5 hour perspective; a randomized controlled study in healthy subjects. Nutr J. 2017 Apr 21;16(1):25. doi: 10.1186/s12937-017-0246-5. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Other |
|
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |