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The experimental model is a semi-acute study where the purpose of the study is to evaluate food factors related to colonially derived regulation of glucose metabolism (and related parameters) and satiety in healthy subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| + ind. CHO + prim | Experimental | Test meal: ate intrinsic indigestible carbohydrates 3 days prior to measurements of variables (priming) |
|
| - ind. CHO + prim | Experimental | Reference:ate no intrinsic indigestible carbohydrates 3 days prior to measurements of variables (priming) |
|
| + ind. CHO - prim | Experimental | Test meal: ate intrinsic indigestible carbohydrates 1 day prior to measurements of variables (no priming) |
|
| - ind. CHO - prim | Experimental | Reference: ate no indigestible carbohydrates the day prior to measurements of variables (no priming). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Test meal | Other |
| ||
| Reference |
| Measure | Description | Time Frame |
|---|---|---|
| Blood glucose | The test products are both ingested one day and three days prior to measurements of variables. | Postprandial 0-180 min after breakfast |
| Insulin | The test products are both ingested one day and three days prior to measurements of variables. | Postprandial 0-180 min after breakfast |
| Appetite hormones | The test products are both ingested one day and three days prior to measurements of variables. | Postprandial 0-180 min after breakfast |
| Markers of colonic fermentation and inflammation | The test products are both ingested one day and three days prior to measurements of variables. | Postprandial 0-180 min after breakfast |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective satiety | The measures of hunger, satiety, and desire to eat with the use of a VAS were determined every hour throughout the postprandial testing sessions. | Postprandial 0-180 min after breakfast |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anne Nilsson, PhD | Lund Univeristy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Applied Nutrition and Food Chemistry, Lund Univeristy | Lund | SE | 221 00 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26990559 | Derived | Sandberg JC, Bjorck IM, Nilsson AC. Rye-Based Evening Meals Favorably Affected Glucose Regulation and Appetite Variables at the Following Breakfast; A Randomized Controlled Study in Healthy Subjects. PLoS One. 2016 Mar 18;11(3):e0151985. doi: 10.1371/journal.pone.0151985. eCollection 2016. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Other |
|
| Priming | Other | The reference or test meal was eaten 3 days prior to measurements of variables. |
|
| No priming | Other | The reference or test meal was eaten 1 days prior to measurements of variables. |
|
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |