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The purpose of the study is to evaluate food factors related to colonically derived regulation of glucose metabolism (and related parameters) and satiety using a semi-acute meal study in healthy subjects as experimental model.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| + ind.CHO + prebiotics | Experimental | test meal: intrinsic indigestible carbohydrates in combination with a combined probiotic supplement. |
|
| + ind.CHO - prebiotics | Experimental | test meal: intrinsic indigestible carbohydrates in combination with placebo probiotic supplement. |
|
| - ind.CHO - prebiotics | Experimental | reference: no ind. carbohydrates and no probiotic supplement |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| test meal | Other |
| ||
| reference |
| Measure | Description | Time Frame |
|---|---|---|
| Differences in concentration of risk markers in blood, measured post-prandial after a breakfast meal. | Variables (blood glucose, insulin, incretin, inflammatory markers, markers of colonic fermentation) are measured after two-weeks ingestion of test products. The experimental day is terminated after a lunch meal. | Post-prandially after breakfast, 0-210 min |
| Measure | Description | Time Frame |
|---|---|---|
| voluntary energy intake | Energy intake at lunch is measured after two-weeks ingestion of test products. The experimental day is terminated after the lunch meal. | Post-prandially after breakfast, 0-210 min |
| Subjective satiety |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anne Nilsson, PhD | Lund University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Applied Nutrition and Food Chemistry, Lund University | Lund | SE-221 00 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28531784 | Derived | Nilsson A, Johansson-Boll E, Sandberg J, Bjorck I. Gut microbiota mediated benefits of barley kernel products on metabolism, gut hormones, and inflammatory markers as affected by co-ingestion of commercially available probiotics: a randomized controlled study in healthy subjects. Clin Nutr ESPEN. 2016 Oct;15:49-56. doi: 10.1016/j.clnesp.2016.06.006. Epub 2016 Jul 2. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Other |
|
The subjective sensation of satiety, hunger and desire to eat is measured using a (VAS) questionnaire.
| post-prandially after breakfast, 0-210 min |
| Differences in gut microbiota | The effect on gut microbiota of 14 days intake of test- and reference product are investigated in faecal samples. | Faecal samples are collected after 14 days intake of test- and reference product |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |