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This study aims at investigating the impact of colonic fermentation of intrinsic indigestible carbohydrates in cereal whole kernels after three days consumption, on metabolic variables and cognition. The study is performed in healthy, normal to slightly over-weight test subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| indigestible carbohydrates | Experimental | test meal: indigestible carbohydrates |
|
| reference | Experimental | reference meal: no indigestible carbohydrates |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| test meal | Other |
| ||
| reference meal |
| Measure | Description | Time Frame |
|---|---|---|
| Area under the plasma concentration versus time curve (AUC) of the test meal | The differences in AUC between different risk markers, assessed in plasma or serum,after intake of the test meal in comparison to the reference meal is measured. Example of variables measured are glucose, insulin, appetite hormones, inflammatory markers, markers of colonic fermentation. | Post-prandially after breakfast, 0-150 min |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive performance | The cognitive performance of the test subjects is measured to investigate work memory and specific attention. | Post-prandially after breakfast, 0-210 min |
| Subjective satiety |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anne Nilsson, PhD | Lund University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Applied Nutrition and Food Chemistry, Lund University | Lund | SE-221 00 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26259632 | Derived | Nilsson AC, Johansson-Boll EV, Bjorck IM. Increased gut hormones and insulin sensitivity index following a 3-d intervention with a barley kernel-based product: a randomised cross-over study in healthy middle-aged subjects. Br J Nutr. 2015 Sep 28;114(6):899-907. doi: 10.1017/S0007114515002524. Epub 2015 Aug 11. |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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|
The subjective sensation of satiety, hunger and desire to eat is measured using a questionnaire.
| post-prandially after breakfast, 0-150 min |
| D009750 |
| Nutritional and Metabolic Diseases |