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| Name | Class |
|---|---|
| Vinnova | OTHER_GOV |
| Öste Venture AB | UNKNOWN |
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The aim of the project is to study the connection between bacterial fermentation in the colon of prebiotic substrates and effects on systemic metabolism and appetite i healthy humans
The purpose with this project is to study the association between bacterial fermentation in the colon of specific mixtures of cereal dietary fiber and effects on systemic metabolism and appetite regulation. For this purpose, short term studies are performed in healthy adult subjects. Different cereals, cereal blends and from cereal extracted dietary fiber will be studied, as well as effects of different processing of the cereals. Cardiometabolic test markers and colonic fermentation metabolites will be followed up to 14 h after intake of the test substrates, and gut microbiota composition will be determined prior to and after the interventions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cereal product 1 | Experimental | Cereal based müsli no. 1, made from typical Swedish cereals. All experimental products have different types and amounts of dietary fibre (df). The test portion is consumed as a single evening meal prior to determinations of test variables in the morning. |
|
| Cereal product 2 | Experimental | Cereal based muesli no. 2 made from typical Swedish cereals. All experimental products have different types and amounts of df. The test portion is consumed as a single evening meal prior to determinations of test variables in the morning. |
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| Cereal product 3 | Experimental | Cereal based muesli no.3 made from typical Swedish cereals. All experimental products have different types and amounts of df.The test portion is consumed as a single evening meal prior to determinations of test variables in the morning. |
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| Cereal product 4 | Experimental | Cereal based muesli no. 4 made from typical Swedish cereals. All experimental products have different types and amounts of df. The test portion is consumed as a single evening meal prior to determinations of test variables in the morning. |
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| Cereal product 5 |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cereal product 1 | Other | Cereal products based on rye, barley, wheat, oat, and corn |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Blood glucose regulation | Postprandial blood glucose regulation (incremental area under the curve) acute after intake of the test products and at forthcoming meals within 14 h after consumption of test products. | 0-14 h after intake |
| Measure | Description | Time Frame |
|---|---|---|
| serum insulin | Postprandial serum insulin concentrations (incremental area under the curve) acute after intake of the test products and at forthcoming meals within 14 h after consumption of test products. | 0-14 h after intake |
| gut microbiota composition |
| Measure | Description | Time Frame |
|---|---|---|
| Subjective appetite sensations | determined with VAS (visual analogue scale) scales (0-100 mm) | 0-14 h after intake |
| mood (valence and activity) | determined with VAS scales (0-100 mm) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anne Nilsson, PhD | Food Technology, engineering, and Nutrition, LTH, Lund University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Food Technology, engineering and Nutrition, LTH, Lund University | Lund | 22100 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20810606 | Background | Nilsson AC, Ostman EM, Knudsen KE, Holst JJ, Bjorck IM. A cereal-based evening meal rich in indigestible carbohydrates increases plasma butyrate the next morning. J Nutr. 2010 Nov;140(11):1932-6. doi: 10.3945/jn.110.123604. Epub 2010 Sep 1. | |
| 26259632 | Background | Nilsson AC, Johansson-Boll EV, Bjorck IM. Increased gut hormones and insulin sensitivity index following a 3-d intervention with a barley kernel-based product: a randomised cross-over study in healthy middle-aged subjects. Br J Nutr. 2015 Sep 28;114(6):899-907. doi: 10.1017/S0007114515002524. Epub 2015 Aug 11. |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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Crossover randomised
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Cereal based muesli no. 5 made from typical Swedish cereals. All experimental products have different types and amounts of df. The test portion is consumed as a single evening meal prior to determinations of test variables in the morning. |
|
| Control product | Placebo Comparator | A cereal based product with low concentrations of df. The control portion is consumed as a single evening meal prior to determinations of test variables in the morning. |
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| Cereal product 2 |
| Other |
Cereal products based on rye, barley, wheat, oat, and corn |
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| Cereal product 3 | Other | Cereal products based on rye, barley, wheat, oat, and corn |
|
| Cereal product 4 | Other | Cereal products based on rye, barley, wheat, oat, and corn |
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| Cereal product 5 | Other | Cereal products based on rye, barley, wheat, oat, and corn |
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| Control product | Other | A cereal based product with low concentrations of df |
|
effects on gut microbiota composition after intake of prebiotics |
| first stool delivered from14 h after intake |
| plasma GLP-1 (glucagon-like peptide-1 ), PYY (peptide tyrosine tyrosine), Ghrelin | Gastro-intestinale hormones involved in appetite and metabolic regulation | 0-14 h after intake |
| plasma: CRP (C reactive protein ), IL (interleukin)-6, IL-18, IL-8, IL-1, IL-10, LBP (lipopolysaccharide-binding protein), (PAI-1plasminogen activator inhibitor) | Inflammatory markers in blood | 0-14 h after intake |
| plasma GLP-2 | gut hormone involved in gut mucosa integrity | 0-14 h after intake |
| plasma SCFA (short-chain fatty acid) | colonic fermentation metabolites | 0-14 h after intake |
| blood lipids | cholesterol and free fatty acids in plasma | 0-14 h after intake |
| plasma adiponectin | hormone involved in metabolic regulation | 0-14 h after intake |
| plasma BDNF (Brain-derived neurotrophic factor) | signal protein important for brain functions, but also involved in metabolic regulation | 0-14 h after intake |
| plasma neurotensin | a neuro peptide peptides involved in appetite and metabolic regulation | 0-14 h after intake |
| plasma Nesfatin-1 | a neuro peptide that participates in the regulation of hunger and fat storage. | 0-14 h after intake |
| 0-14 h after intake |
| Energy intake | ad libitum intake at a second meal after intake of test products | 4 h after intake of a test product or the control product |
| breath hydrogen concentrations | indicator of gut fermentation | 0-14 h after intake |
| 26552345 | Background | Kovatcheva-Datchary P, Nilsson A, Akrami R, Lee YS, De Vadder F, Arora T, Hallen A, Martens E, Bjorck I, Backhed F. Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella. Cell Metab. 2015 Dec 1;22(6):971-82. doi: 10.1016/j.cmet.2015.10.001. Epub 2015 Nov 6. |
| 26990559 | Background | Sandberg JC, Bjorck IM, Nilsson AC. Rye-Based Evening Meals Favorably Affected Glucose Regulation and Appetite Variables at the Following Breakfast; A Randomized Controlled Study in Healthy Subjects. PLoS One. 2016 Mar 18;11(3):e0151985. doi: 10.1371/journal.pone.0151985. eCollection 2016. |
| 28431559 | Background | Sandberg JC, Bjorck IME, Nilsson AC. Effects of whole grain rye, with and without resistant starch type 2 supplementation, on glucose tolerance, gut hormones, inflammation and appetite regulation in an 11-14.5 hour perspective; a randomized controlled study in healthy subjects. Nutr J. 2017 Apr 21;16(1):25. doi: 10.1186/s12937-017-0246-5. |
| 18356328 | Background | Nilsson AC, Ostman EM, Holst JJ, Bjorck IM. Including indigestible carbohydrates in the evening meal of healthy subjects improves glucose tolerance, lowers inflammatory markers, and increases satiety after a subsequent standardized breakfast. J Nutr. 2008 Apr;138(4):732-9. doi: 10.1093/jn/138.4.732. |
| D008722 | Methods |