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The purpose of the study is to examine how a dietary fiber affects metabolism in healthy overweight and obese adults. The fiber will be added to foods that participants will consume for two, three-week periods. The fiber will be given in two doses -- 15 g per day during one period, and 30 g per day in the other. In another three-week period, they will consume the same foods, but with no fiber added. Major outcomes will include fermentability of the fiber, as assessed by measurement of breath hydrogen, as well as shifts in fecal bacteria. The caloric value of the fiber will be determined and metabolic measures related to blood glucose control and inflammation will also be taken.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low dose dietary fiber | Experimental |
| |
| High dose dietary fiber | Experimental |
| |
| No added fiber | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary Fiber | Dietary Supplement | Dietary fiber will be added to study foods |
|
| Measure | Description | Time Frame |
|---|---|---|
| Metabolizable energy | Urine and feces will be collected for 7 days at the end of each treatment period to allow for assessment of metabolizable energy | 7 days, 3 times |
| Fermentability | Breath hydrogen will be measured hourly, over eight hours at the end of each treatment period | One, eight-hr day, three times |
| Measure | Description | Time Frame |
|---|---|---|
| Fecal microbiota | Fecal samples will be collected for 7 days at the end of each treatment period and for two days during washout periods | 2 days, three times, and 7 days, three times |
| Blood glucose |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nancy Keim, PhD | ARS/USDA, University of California - Davis | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| USDA, ARS, Western Human Nutrition Research Center | Davis | California | 95616 | United States |
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| ID | Term |
|---|---|
| D004043 | Dietary Fiber |
| ID | Term |
|---|---|
| D004040 | Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
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An indwelling catheter will be placed and blood samples will be drawn over the course of an eight-hour period, at the end of each treatment period
| For eight hours, three times |
| D010829 |
| Physiological Phenomena |
| D019602 | Food and Beverages |