Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The excess production of colonic short-chain-fatty-acids (SCFA) has been implicated in the promotion of obesity, but colonic fermentation of dietary-fiber to SCFA may also play a role in preventing diabetes. The investigators aimed to compare the effects of two fermentable fibers (inulin and resistant-starch) on postprandial SCFA, glucose, insulin, free-fatty acids (FFA) and gut hormone responses and to compare the responses in healthy overweight and obese (OWO) vs lean (LN) participants. Methods: Using a randomized, single blind, crossover design, 13 OWO and 12 LN overnight fasted participants were studied on 3 separate occasions. On each day they consumed a 300 mL drink containing 75g glucose (Control) or 75g glucose plus 24g inulin (IN), or 28.2g resistant-starch (RS). A standard lunch was served 4 h after the test drink.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lean | Other | Participants with body mass index <=25 |
|
| Overweight | Other | Participants with body mass index >25 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Glucose | Other | 75g glucose |
| |
| Inulin |
| Measure | Description | Time Frame |
|---|---|---|
| Incremental area under the serum acetate response curve | For 6 hours after consuming the test meal |
| Measure | Description | Time Frame |
|---|---|---|
| Incremental area under the serum propionate response curve | For 6 hours after consuming the test meal | |
| Incremental area under the serum butyrate response curve | For 6 hours after consuming the test meal |
| Measure | Description | Time Frame |
|---|---|---|
| Incremental area under the serum glucagon-like peptide-1 response curve | For 4 hours after consuming the test meal | |
| Incremental area under the serum glucagon-like peptide-1 response curve | For 2 hours after consuming the standard lunch |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Thomas MS Wolever, MD, PhD | University of Toronto | Principal Investigator |
Not provided
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27966574 | Derived | Rahat-Rozenbloom S, Fernandes J, Cheng J, Wolever TMS. Acute increases in serum colonic short-chain fatty acids elicited by inulin do not increase GLP-1 or PYY responses but may reduce ghrelin in lean and overweight humans. Eur J Clin Nutr. 2017 Aug;71(8):953-958. doi: 10.1038/ejcn.2016.249. Epub 2016 Dec 14. | |
| 27966565 | Derived |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D005947 | Glucose |
| D007444 | Inulin |
| D000084922 | Resistant Starch |
| ID | Term |
|---|---|
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
| D013213 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Other |
75g glucose plus 24g inulin |
|
| Resistant Starch | Other | 75g glucose plus 28.2g resistant starch |
|
| Incremental area under the breath hydrogen response curve | For 6 hours after consuming the test meal |
| Incremental area under the breath methane response curve | For 6 hours after consuming the test meal |
| Incremental area under the serum glucose response curve | For 4 hours after consuming the test meal |
| Incremental area under the serum glucose response curve | For 2 hours after consuming the standard lunch |
| Incremental area under the serum insulin response curve | For 4 hours after consuming the test meal |
| Incremental area under the serum insulin response curve | For 2 hours after consuming the standard lunch |
| Incremental area under the serum c-peptide response curve | For 4 hours after consuming the test meal |
| Incremental area under the serum c-peptide response curve | For 2 hours after consuming the standard lunch |
| Total area under the serum free-fatty acid response curve | For 4 hours after consuming the test meal |
| Total area under the serum free-fatty acid response curve | For 2 hours after consuming the standard lunch |
| Incremental area under the serum peptide-YY response curve | For 4 hours after consuming the test meal |
| Incremental area under the serum peptide-YY response curve | For 2 hours after consuming the standard lunch |
| Incremental area under the serum ghrelin response curve | For 4 hours after consuming the test meal |
| Incremental area under the serum ghrelin response curve | For 2 hours after consuming the standard lunch |
| Rahat-Rozenbloom S, Fernandes J, Cheng J, Gloor GB, Wolever TM. The acute effects of inulin and resistant starch on postprandial serum short-chain fatty acids and second-meal glycemic response in lean and overweight humans. Eur J Clin Nutr. 2017 Feb;71(2):227-233. doi: 10.1038/ejcn.2016.248. Epub 2016 Dec 14. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| Starch |
| D005936 | Glucans |
| D001704 | Biopolymers |
| D011108 | Polymers |
| D046911 | Macromolecular Substances |
| D004040 | Dietary Carbohydrates |
| D005630 | Fructans |
| D011134 | Polysaccharides |
| D004043 | Dietary Fiber |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |