Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2

Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2

Before, during and after intravenous administration of PGE2 we score/measure headache, rCBF, blood flow in the middle cerebral artery and diameter of superficial temporal artery and correlate that to known pathophysiology of headache to see if PGE2 is involved in headache pathophysiology.

Inclusion Criteria:

• Healthy volunteers

Exclusion Criteria:

• Primary Headache, headache on the day of the investigation, hypertension, hypotension, pregnant/nursing, daily intake of medication (except oral contraceptives), Cardiovascular or CNS disease, drug/alcohol abuse, psychiatric disease