Prostaglandin E2 in Migraine Suffers Without Aura.

Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of Prostaglandin E2 in Migraine Suffers Without Aura.

The hypothesis of this study is that Prostaglandin E2 (PGE2) induces headache and dilatation of brain vessels in migraine patients without aura.

Inclusion Criteria:

• Patients with migraine without aura

Exclusion Criteria:

• Tension type headache more than x 3 per month
• Other forms for primary headache
• Headache 24 h before the day of the investigation
• Migraine 48 h before the day of the investigation
• Hypertension
• Hypotension
• Pregnant/nursing
• Daily intake of medication (except oral contraceptives and migraine rescue medicine during migraine attack)
• Cardiovascular or central nervous system (CNS) disease
• Drug/alcohol abuse
• Psychiatric disease
• Asthma or any other lung diseases