Migraine Inducing Effects and Changes in Brain Haemodynamics of PGI2

Migraine Inducing Effects and Changes in Brain Haemodynamics of PGI2

We hypothesised that intravenous infusion of PGI2 induced headache or migraine and cranial vasodilatation in migraineurs.

Inclusion Criteria:

• migraine without aura and healthy apart from that
• age 18-55 years
• 50-100 kg
• Secure contraceptives

Exclusion Criteria:

• Tension Type Headache more than 3 time a month
• Other primary headaches
• Medication prior to the study (closer than 4 times plasma halflife)
• Migraine or headache 5 days prior to study.
• Hypertension (systolic BP >150 mmHg and/or diastolic BP >100 mmHg).
• Hypotension (systolic BP <90 mmHg and/or diastolic BP <50 mmHg).
• Heart-vessel disease of any kind incl cerebrovascular disease.
• Anamnestic or clinical signs of psychiatric disease or abuse.
• Anamnestic or clinical signs of disease of any kind relevant for participation in the study.