PGI2 Induced Headache and Cerebral Haemodynamics in Healthy Volunteers

Before , during and after intravenous administration of PGI2 we score/measure headache, rCBF, blood flow in middle cerebral artery and diameter of superficial temporal artery/radial artery and correlate that to known patophysiology of headache to see if PGI2 is involved in headache pathophysiology.

Inclusion Criteria:

• Healthy volunteers,

Exclusion Criteria:

• Primary headache,
• headache on the day of investigation,
• Hypertension,
• hypotension,
• pregnant/nursing
• Daily intake of medication (except oral contraceptives)
• Cardiovascular or CNS disease
• Drug/Alcohol abuse
• Psychiatric disease