EP4-receptor Antagonism and Prostaglandin E2 (PGE2) in a Human Headache Model

EP4-receptor Antagonism and Prostaglandin E2 (PGE2) in a Human Headache Model

The purpose of this study is to determine whether EP-4 receptor antagonist can prevent the headache expected during a Prostaglandin E2 infusion.

Inclusion Criteria:

• Healthy volunteers

Exclusion Criteria:

• Tension headache
• All other primary forms of headache
• Cardiovascular, Central Nervous system (CNS) and autoimmune diseases
• Gastrointestinal disease
• Previous or clinical signs of mental illness or substance abuse.
• Participation in a clinical study of a medicinal product without regulatory approval or marketing authorisation within 1 month prior to this trial
• Pregnancy/nursing
• Daily intake of medication (except oral contraceptives)