PACAP38´s (Pituitary Adenylate Cyclase-Activating Polypeptide) Headache Inducing Characteristics and Effects on the Cerebral Blood Flow

Basic Scientific Research Investigating PACAP38 Headache Inducing Effects in Migraine Patients

To investigate headache score and accompanying symptoms during and after infusion of PACAP38 i migraine patients

To investigate headache score and accompanying symptoms during and after infusion of PACAP38

Changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery (MCA), blood flow in MCA, diameter of the superficial temporal artery (STA) and radial artery (RA)

Inclusion Criteria:

• Healthy migraine patient without aura
• Aged 18-50
• 50-100 kg
• Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.

Exclusion Criteria:

• Tension type headache more than five times/month
• Other primary headaches
• Daily medication except contraceptives
• Drug taken within 4 times the halflife for the specific drug except contraceptives
• Pregnant or lactating women
• Exposure to radiation within the last year
• Headache within the last 48 hours before start of trial
• Hypertension
• Hypotension
• Respiratory or cardiac disease