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| ID | Type | Description | Link |
|---|---|---|---|
| R01DA008391 | U.S. NIH Grant/Contract | View source | |
| R01-08391-14 |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
The purpose of this study is to determine the effects of combined sevoflurane and nitrous oxide inhalation on mood, psychomotor performance, and the pain response in humans.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo +/- 30% Nitrous oxide | Placebo Comparator |
| |
| Sevoflurane 0.2% +/- 30% Nitrous oxide | Active Comparator |
| |
| Sevoflurane 0.4% +/- 30% Nitrous oxide | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 30% Nitrous oxide | Drug |
| ||
| Measure | Description | Time Frame |
|---|---|---|
| Pain intensity, pain bothersomeness | Inhalation was for 68 min divided into 4 blocks with nitrous oxide added during either block 2 or block 4 | During inhalation |
| Mood | Inhalation was for 68 min divided into 4 blocks with nitrous oxide added during either block 2 or block 4 | During inhalation |
| Psychomotor performance | Inhalation was for 68 min divided into 4 blocks with nitrous oxide added during either block 2 or block 4 | During inhalation |
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Please contact site for information.
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| Name | Affiliation | Role |
|---|---|---|
| James Zacny, Ph.D. | University of Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Chicago, Anesthesia & Critical Care | Chicago | Illinois | 60637 | United States |
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| ID | Term |
|---|---|
| D009293 | Opioid-Related Disorders |
| D019966 | Substance-Related Disorders |
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D000079524 | Narcotic-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
| D010468 | Perceptual Disorders |
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| ID | Term |
|---|---|
| D009609 | Nitrous Oxide |
| D000077149 | Sevoflurane |
| ID | Term |
|---|---|
| D009589 | Nitrogen Oxides |
| D005740 | Gases |
| D007287 | Inorganic Chemicals |
| D017672 | Nitrogen Compounds |
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| 0.4% Sevoflurane |
| Drug |
|
| 0.2% sevoflurane | Drug |
|
| Placebo | Other |
|
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010087 |
| Oxides |
| D017601 | Oxygen Compounds |
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |