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| ID | Type | Description | Link |
|---|---|---|---|
| R01DA008391 | U.S. NIH Grant/Contract | View source | |
| R01-08391-6 |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To test the hypothesis that isoflurane at subanesthetic concentrations does not reduce cold-water immersion pain in healthy volunteers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0% isoflurane | Sham Comparator |
| |
| 0.2% isoflurane | Active Comparator |
| |
| 0.4% isoflurane | Active Comparator |
| |
| 0.6% isoflurane | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 40% Nitrous oxide | Drug | Used as pain assay positive control |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pain response | Effects of inhaled isoflurane on pain from immersion of subject's arm in ice cold water. Nitrous oxide (40%) was used as a positive control to confirm sensitivity of the pain assay. | Post inhalation |
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Please contact site for information.
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| Name | Affiliation | Role |
|---|---|---|
| James Zacny, Ph.D. | University of Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Chicago, Anesthesia & Critical Care | Chicago | Illinois | 60637 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | Anesthesiology, 1995, 83: A287 |
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| ID | Term |
|---|---|
| D009293 | Opioid-Related Disorders |
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D000079524 | Narcotic-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D009609 | Nitrous Oxide |
| D007530 | Isoflurane |
| ID | Term |
|---|---|
| D009589 | Nitrogen Oxides |
| D005740 | Gases |
| D007287 | Inorganic Chemicals |
| D017672 | Nitrogen Compounds |
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| Sham comparator | Other | 0% isoflurane in oxygen |
|
| 0.2% isoflurane | Drug |
|
| 0.4% isoflurane | Drug |
|
| 0.6% isoflurane | Drug |
|
| D010087 |
| Oxides |
| D017601 | Oxygen Compounds |
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |