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| ID | Type | Description | Link |
|---|---|---|---|
| R01DA008391 | U.S. NIH Grant/Contract | View source | |
| R01-08391-1 |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | Subject inhaled 0% N2O for 40 minutes with cold immersion at 10 and 30 minutes | |
| 20% N2O | Active Comparator | Subject inhaled 20% N2O for 40 minutes with cold immersion at 10 & 30 minutes |
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| 30% N2O | Active Comparator | Subject inhaled 30% N2O for 40 minutes with cold immersion at 10 and 30 minutes |
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| 40% N2O | Active Comparator | Subject inhaled 40% N2O for 40 minutes with cold immersion at 10 and 30 minutes |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 20% N2O | Drug | 20% inhaled N2O |
| |
| 30% N2O |
| Measure | Description | Time Frame |
|---|---|---|
| Pain intensity | Subjects immersed non-dominant arm for 3 minutes twice in 2-3 degree C water while inhaling 0 (placebo), 20, 30, or 40% N2O for a total of 40 minutes | during cold test at 10 min & 30 min of inhalation |
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Please contact site for information.
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| Name | Affiliation | Role |
|---|---|---|
| James Zacny, Ph.D. | University of Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Chicago, Anesthesia & Critical Care | Chicago | Illinois | 60637 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 7667348 | Background | Pirec V, Patterson TH, Thapar P, Apfelbaum JL, Zacny JP. Effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans. Pharmacol Biochem Behav. 1995 Jun-Jul;51(2-3):323-9. doi: 10.1016/0091-3057(94)00388-y. |
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| ID | Term |
|---|---|
| D009293 | Opioid-Related Disorders |
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D000079524 | Narcotic-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| Drug |
30% inhaled N2O |
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| 40% N2O | Drug | 40% inhaled N2O |
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