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| ID | Type | Description | Link |
|---|---|---|---|
| R01DA008391 | U.S. NIH Grant/Contract | View source | |
| R01-08391-4 |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine the lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0% N2O | Sham Comparator | Subjects will inhale 0% N2O |
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| 10% N2O | Active Comparator | Subjects will inhale 10% N2O |
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| 20% N2O | Active Comparator | Subjects will inhale 20% N2O |
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| 30% N2O | Active Comparator | Subjects will inhale 30% N2O |
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| 40% N2O | Active Comparator | Subjects will inhale 40% N2O |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 0% N2O | Drug |
| ||
| 10% N2O |
| Measure | Description | Time Frame |
|---|---|---|
| Psychomotor performance | Subjects will undergo psychomotor testing during 120 min inhalation session of each intervention | During inhalation |
| Cognitive performance | Subjects will under cognitive testing during 120 minute inhalation session of each intervention | During inhalation |
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Please contact site for information.
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| Name | Affiliation | Role |
|---|---|---|
| James Zacny, Ph.D. | University of Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Chicago, Anesthesia & Critical Care | Chicago | Illinois | 60637 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 8743615 | Background | Yajnik S, Zacny JP, Young CJ, Lichtor JL, Rupani G, Klafta JM, Coalson DW, Apfelbaum JL. Lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers. Pharmacol Biochem Behav. 1996 Jun;54(2):501-8. doi: 10.1016/0091-3057(95)02278-3. |
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| ID | Term |
|---|---|
| D009293 | Opioid-Related Disorders |
| D019966 | Substance-Related Disorders |
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D000079524 | Narcotic-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
| D010468 | Perceptual Disorders |
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| 20% N2O | Drug |
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| 30% N2O | Drug |
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| 40% N2O | Drug |
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| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |