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| ID | Type | Description | Link |
|---|---|---|---|
| R01DA008391 | U.S. NIH Grant/Contract | View source | |
| R01-08391-5 |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine the subjective, psychomotor, and reinforcing effects of nitrous oxide in healthy volunteers. This is a dose-response analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo + 10% N2O | Active Comparator | 0% N2O inhaled during psychomotor testing, 10% N2O inhaled during psycho motor testing, then subject's choice of the 2. |
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| Placebo + 20% N2O | Active Comparator | Placebo inhaled during psychomotor testing, 20% N2O inhaled during psychomotor testing, then subject's choice of the 2. |
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| Placebo + 30% N2O | Active Comparator | Placebo inhaled during psychomotor testing, 30% N2O inhaled during psychomotor testing, then subject's choice of the 2. |
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| Placebo + 40% N2O | Active Comparator | Placebo inhaled during psychomotor testing, 40% N2O inhaled during psychomotor testing, then subject's choice of the 2. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 10% N2O | Drug |
| ||
| 20% N2O |
| Measure | Description | Time Frame |
|---|---|---|
| Choice of N2O vs. placebo | Subjects underwent 4 sessions consisting of 2 sample tests (inhaling placebo and inhaling varying doses of N2O), then choosing which inhalant they wanted for a choice test. The subject & the technician administering the inhalant were blinded. During each intervention and each session, subjects underwent psychomotor testing. | After each pair of sample tests |
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Please contact site for information.
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| Name | Affiliation | Role |
|---|---|---|
| James Zacny, Ph.D. | University of Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Chicago, Anesthesia & Critical Care | Chicago | Illinois | 60637 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | Behavioral Pharmacology, 1996, 7: 194-199. |
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| ID | Term |
|---|---|
| D009293 | Opioid-Related Disorders |
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D000079524 | Narcotic-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| 30% N2O | Drug |
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| 40% N2O | Drug |
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