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| ID | Type | Description | Link |
|---|---|---|---|
| R01DA008391 | U.S. NIH Grant/Contract | View source | |
| R01-08391-3 |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations in healthy volunteers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Subjects inhale 100% oxygen |
|
| 30% N2O | Active Comparator | Subjects inhale 30% N2O |
|
| 0.2% isoflurane | Active Comparator | Subjects inhale 0.2% isoflurane |
|
| 0.4% isoflurane | Active Comparator | Subjects inhale 0.4% isoflurane |
|
| 0.2% isoflurane + 30% N2O | Active Comparator | Subjects will inhale a combination of 0.2% isoflurane and 30% N2O |
|
| 0.4% isoflurane + 30% N2O | Active Comparator | Subjects will inhale a combination of 0.4% isoflurane and 30% N2O |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 30% N2O | Drug |
| ||
| 0.2% isoflurane |
| Measure | Description | Time Frame |
|---|---|---|
| Logical reasoning test | 15 & 30 min inhalation and 5, 30, & 60 min post inhalation | |
| Free recall memory test | 15 & 30 min inhalation and 5, 30, & 60 min post inhalation | |
| Auditory reaction time | 15 & 30 min inhalation and 5,30 & 60 min post inhalation | |
| Digit symbol substitution test | 2,15 & 30 min inhalation and 5,30 & 60 min post inhalation |
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Please contact site for information.
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| Name | Affiliation | Role |
|---|---|---|
| James Zacny, Ph.D. | University of Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Chicago, Anesthesia & Critical Care | Chicago | Illinois | 60637 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 8712393 | Background | Zacny JP, Yajnik S, Lichtor JL, Klafta JM, Young CJ, Thapar P, Rupani G, Coalson DW, Apfelbaum JL. The acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations on cognitive and psychomotor performance in healthy volunteers. Anesth Analg. 1996 Jan;82(1):153-7. doi: 10.1097/00000539-199601000-00028. | |
| 29610659 | Derived | Whelan J, Hackshaw A, McTiernan A, Grimer R, Spooner D, Bate J, Ranft A, Paulussen M, Juergens H, Craft A, Lewis I. Survival is influenced by approaches to local treatment of Ewing sarcoma within an international randomised controlled trial: analysis of EICESS-92. Clin Sarcoma Res. 2018 Mar 30;8:6. doi: 10.1186/s13569-018-0093-y. eCollection 2018. |
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| ID | Term |
|---|---|
| D009293 | Opioid-Related Disorders |
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D000079524 | Narcotic-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D007530 | Isoflurane |
| D010100 | Oxygen |
| ID | Term |
|---|---|
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D018011 | Chalcogens |
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| Drug |
|
| 0.4% isoflurane | Drug |
|
| 100% oxygen | Other | Placebo |
|
| D004602 |
| Elements |
| D007287 | Inorganic Chemicals |
| D005740 | Gases |