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| ID | Type | Description | Link |
|---|---|---|---|
| R01DA008391 | U.S. NIH Grant/Contract | View source | |
| R01-08391-11 |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine sevoflurane versus isoflurane inhalation at subanesthetic concentrations on mood, pain, and psychomotor performance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Subject inhales no drug (100% oxygen) |
|
| 0.3% sevoflurane | Active Comparator |
| |
| 0.6% sevoflurane | Active Comparator |
| |
| 15% Nitrous oxide | Active Comparator |
| |
| 30% Nitrous oxide | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 15 % Nitrous oxide | Drug |
| ||
| 0.3 % Sevoflurane |
| Measure | Description | Time Frame |
|---|---|---|
| Pain intensity | Subjects underwent a 3 min cold immersion test at 30 min of inhalation and then provided response to pain intensity questionnaire | 30 min of inhalation |
| Psychomotor performance | Subjects underwent psychomotor testing at baseline, during inhalation, and during recovery post inhalation | Baseline, 5 min of inhalation; 5, 30, 60 minutes recovery |
| Cognitive performance | Subject underwent memory, sedation, visual analog, and drug effects testing | Baseline, every 5 min during inhalation, 5, 30, & 60 min during recovery |
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Please contact site for information.
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| Name | Affiliation | Role |
|---|---|---|
| James Zacny, Ph.D. | University of Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Chicago, Anesthesia & Critical Care | Chicago | Illinois | 60637 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | Anesthesiology. 1997 (in press). |
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| ID | Term |
|---|---|
| D009293 | Opioid-Related Disorders |
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D000079524 | Narcotic-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D009609 | Nitrous Oxide |
| D000077149 | Sevoflurane |
| ID | Term |
|---|---|
| D009589 | Nitrogen Oxides |
| D005740 | Gases |
| D007287 | Inorganic Chemicals |
| D017672 | Nitrogen Compounds |
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|
| 30% Nitrous oxide | Drug |
|
| 0.6% Sevoflurane | Drug |
|
| Placebo | Other |
|
| D010087 |
| Oxides |
| D017601 | Oxygen Compounds |
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |