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| ID | Type | Description | Link |
|---|---|---|---|
| R01DA008391 | U.S. NIH Grant/Contract | View source | |
| R01-08391-13 |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
The purpose of this study is to evaluate the effects of alcohol history on the subjective and reinforcing effects of sevoflurane and nitrous oxide in healthy volunteers. All subjects underwent psychomotor testing during 4 sessions of placebo, drug/placebo, and choice of intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Moderate drinking adults | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 30% Nitrous oxide | Drug |
| ||
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Mood | Baseline, inhalation, recovery | |
| Psychomotor performance | Baseline, inhalation, recovery | |
| Choice of drug vs placebo | After placebo and drug in each session |
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Please contact site for information.
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| Name | Affiliation | Role |
|---|---|---|
| James Zacny, Ph.D. | University of Chicago | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Chicago, Anesthesia & Critical Care | Chicago | Illinois | 60637 | United States |
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| ID | Term |
|---|---|
| D019973 | Alcohol-Related Disorders |
| D009293 | Opioid-Related Disorders |
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
| D000079524 | Narcotic-Related Disorders |
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| ID | Term |
|---|---|
| D009609 | Nitrous Oxide |
| D000077149 | Sevoflurane |
| ID | Term |
|---|---|
| D009589 | Nitrogen Oxides |
| D005740 | Gases |
| D007287 | Inorganic Chemicals |
| D017672 | Nitrogen Compounds |
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No drug (100% oxygen) |
|
| 0.2% sevoflurane | Drug |
|
| 0.4% sevoflurane | Drug |
|
| 0.6% sevoflurane | Drug |
|
| D010087 |
| Oxides |
| D017601 | Oxygen Compounds |
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |