Inclusion Criteria:

• Are 21 to 49 years old.
• Are female, have not yet gone through menopause, and expect to have a menstrual period during the study.
• Have a cervix (have not had a hysterectomy that removed the cervix). Had a routine high-risk HPV (human papillomavirus) test within the past 90 days and received a valid result (positive or negative).
• Receive medical care at the participating clinic and have been identified by the study team as a possible candidate for the study.
• Can read, understand, and communicate in English.
• Are willing and able to follow study procedures, including using a menstrual blood collection kit and returning the sample for testing.
• Are willing to provide informed consent before any study procedures are performed.
• May be of any race or ethnicity.

Exclusion Criteria:

• Had an HPV test in the past 90 days, but the result was unclear, invalid, or could not be interpreted.
• Are currently pregnant.
• Have had a hysterectomy that removed the cervix.
• Are not currently having menstrual periods or are unable to provide a menstrual blood sample during the study period.
• Have a medical, mental health, cognitive, social, or other condition that, in the opinion of the study doctor, could make it difficult to safely participate or complete the study procedures.
• Are unable to understand the study requirements, use the collection kit, or return the sample for testing.
• Do not wish to participate, withdraw consent, or are unwilling to complete the required study procedures.
• Are taking part in another research study or have another circumstance that, in the opinion of the study team, could affect study results or participant safety.
• Are currently incarcerated.