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Interest in identifying low GI foods and the food factors responsible for the low GI of foods has increased. Three corn products with varying levels of refined and whole grain corn will be compared to each other and to a dextrose control. It is hypothesized that higher levels of whole grain corn present in a food will decrease the rate of absorption and result in a lower postprandial glucose levels and glycemic index, and that the whole grain ingredient manufacturing process impacts whole grain ingredient benefits.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dextrose control | Active Comparator | Consumed at two visits (first and last of 5 test days). Solution contains 25g of available carbohydrates (27.3g dextrose monohydrate) mixed with 250 ml of water. Served with 250 ml additional water. |
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| Control food | Active Comparator | Refined corn snack, served with 250 ml water |
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| Test food A | Experimental | Whole grain corn snack, manufacturer A, served with 250 ml water |
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| Test food B | Experimental | Whole grain corn snack, manufacturer B, served with 250 ml water |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Corn snack containing 25 grams available carbohydrate | Other | Varying amounts of whole-grain corn from none to some to more |
|
| Measure | Description | Time Frame |
|---|---|---|
| iAUC (incremental area under the curve) | Compare the plasma glucose in mmol/L of three corn products | Change from fasting baseline (-5 minutes and 0 minutes) to 15, 30, 45, 60, 90 and 120 minutes after test snack consumed within 10 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Glycemic Index (GI) | Compare the plasma glucose in mmol/L of three products with varying levels of refined and whole grain corn vs. dextrose control | Change from fasting baseline (-5 minutes and 0 minutes) to 15, 30, 45, 60, 90 and 120 minutes after test snack consumed within 10 minutes |
| Glycemic load (GL) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Thomas MS Wolever, MD, PhD | INQUIS Clinical Research, Inc. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| INQUIS Clinical Research | Toronto | Ontario | M5C 2N8 | Canada |
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| ID | Term |
|---|---|
| D002145 | Callosities |
| ID | Term |
|---|---|
| D007642 | Keratosis |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| Dextrose control | Other | A solution containing 25g of available carbohydrates on 2 separate occasions |
|
Calculate the GI x (grams available carbohydrate in a serving) where a serving is 28 grams of each of the three corn products |
| Change from fasting baseline (-5 minutes and 0 minutes) to 15, 30, 45, 60, 90 and 120 minutes after test snack consumed within 10 minutes |
| Incremental glucose levels | Compare glucose levels in mmol/L at individual timepoints after each of three corn products | Change from fasting baseline (-5 minutes and 0 minutes) to 15, 30, 45, 60, 90 and 120 minutes after test corn snack consumed within 10 minutes |